Natural Amino Acid Building Blocks for Peptide Synthesis

Matthias Junkers

With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.1 Today, the most common synthetic approaches to medium and even large peptides follow the Boc/Bzl or Fmoc/tBu solid phase peptide synthesis strategies.2 A convenient list of the most popular Boc- and Fmoc-protected amino acid building blocks for these two synthesis strategies can be found in this issue. The Boc-protected amino acids are also frequently used in solution phase peptide synthesis procedures.

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References

1.
2005. WATCHING PEPTIDE DRUGS GROW UP. Chem. Eng. News. 83(11):17-24. http://dx.doi.org/10.1021/cen-v083n011.p017
2.
Hruby VJ. 2002. Houben?Weyl Methods of Organic Chemistry. Volume E22A. Synthesis of Peptides and Peptidomimetics Edited by Murray Goodman, Arthur Felix, Luis Moroder, and Claudio Toniolo. Georg Thieme Verlag, Stuttgart, Germany. 2001. xxvii + 901 pp. 18 × 26 cm. ISBN 3 132 19604 5. 1840 euro.. J. Med. Chem.. 45(23):5187-5187. http://dx.doi.org/10.1021/jm020371l

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