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Traditional Strong and Hindered Bases

Although we offer specialized bases, such as the phosphazene or Verkade's bases, we also offer traditional bases, such as DBU, DBN, n-BuLi etc (Tables 2, 3 and 4). These traditional strong and/or hindered bases are well known and frequently used tools in organic synthesis. For example, Proton Sponge® (14795) is an extremely strong base for a tertiary amine. Protonation releases the strain of the two amines, resulting in a so-called "Proton Sponge". Table 1 shows the basicity strength for some of our traditional bases.

Table 1.Basicity strength of some traditonal bases.

*Absolute values in acetonitrile. Data obtained from Prof. Dr. Schwesinger, University of Freiburg, Germany

The general strength of the traditional lithium bases follows the order:
LDA < MeLi < n-BuLi < sec-BuLi < tert-BuLi

Table 2.Amine-based traditional bases
Table 3.Lithium-based traditional bases
Table 4.Potassium-based traditional bases