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Merck

APP

amyloid beta (A4) precursor protein

Synonyms:
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
Species:
Human APP (351), Mouse App (11820), Rat App (54226), fruit fly app (39399), chicken APP (374198), dog APP (403407), domestic cat APP (101085564), cow APP (280722), sheep APP (101111593), domestic guinea pig App (100715302)
UniProtKB ID:
P05067, B2R5V1, B4DII8, D3DSD1, D3DSD2, D3DSD3, P09000, P78438
Gene ID:
  • Human(351) Summary: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(11820) amyloid beta (A4) precursor protein
  • Rat(54226) amyloid beta (A4) precursor protein
  • fruit fly(39399) approximated
  • chicken(374198) amyloid beta (A4) precursor protein
  • dog(403407) amyloid beta (A4) precursor protein
  • domestic cat(101085564) amyloid beta (A4) precursor protein
  • cow(280722) amyloid beta (A4) precursor protein
  • sheep(101111593) amyloid beta (A4) precursor protein
  • domestic guinea pig(100715302) amyloid beta (A4) precursor protein
  • naked mole-rat(101724743) amyloid beta (A4) precursor protein

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Small Molecule - Antagonist

Product Number
Description
Species
658960
2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, 97%,
Species
human
B9934
BTA-1, ≥98% (HPLC), solid,
Species
human
07551
Vanillylidenacetone, ≥98.5%,
Species
human
C7727
Curcumin, ≥94% (curcuminoid content), ≥80% (Curcumin),
Species
human
C1386
Curcumin, from Curcuma longa (Turmeric), powder,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
PC150
Anti-β-Amyloid (1-42) Rabbit pAb, liquid, Calbiochem®,
Species Reactivity
human
Application
MAB348
Anti-APP A4 Antibody, a.a. 66-81 of APP {NT}, clone 22C11, clone 22C11, Chemicon®, from mouse,
Species Reactivity
canine, fish, human, monkey, mouse, pig, rat
Application
immunofluorescence
immunohistochemistry
western blot
A8354
Anti-β-Amyloid antibody, Mouse monoclonal, clone NAB 228, purified from hybridoma cell culture,
Species Reactivity
human
Application
ELISA
immunohistochemistry
immunoprecipitation (IP)
microarray
western blot
A8978
Anti-β-Amyloid (13-28) antibody, Mouse monoclonal, clone BAM90.1, purified from hybridoma cell culture,
Species Reactivity
human
Application
enzyme immunoassay
immunohistochemistry
immunoprecipitation (IP)
western blot
A3981
Anti-β-Amyloid antibody, Mouse monoclonal, clone BAM-10, purified from hybridoma cell culture,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot

Proteins

Product Number
Description
Species
A2201
Amyloid β-Protein Fragment 35-25, ≥95% (HPLC),
Species
human
S4316
Amyloid Precursor Protein β, Secreted human, recombinant, expressed in E. coli (N-terminal histidine tagged), solution,
Species
human
A6933
Acetyl-Amyloid β-Protein Fragment 15-20 Amide, ≥97% (HPLC), powder,
Species
human
AG968
β Amyloid 1-42, aβ, ultra pure, HFIP, recombinant human, ,
Species
human
SCP0029
[Gly22]-Amyloid β 1-40 Arctic human, ≥95% (HPLC),
Species
human