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Merck

APP

amyloid beta (A4) precursor protein

Synonyms:
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
Species:
Human APP (351), Mouse App (11820), Rat App (54226), fruit fly app (39399), chicken APP (374198), dog APP (403407), domestic cat APP (101085564), cow APP (280722), sheep APP (101111593), domestic guinea pig App (100715302)
UniProtKB ID:
P05067, B2R5V1, B4DII8, D3DSD1, D3DSD2, D3DSD3, P09000, P78438
Gene ID:
  • Human(351) Summary: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(11820) amyloid beta (A4) precursor protein
  • Rat(54226) amyloid beta (A4) precursor protein
  • fruit fly(39399) approximated
  • chicken(374198) amyloid beta (A4) precursor protein
  • dog(403407) amyloid beta (A4) precursor protein
  • domestic cat(101085564) amyloid beta (A4) precursor protein
  • cow(280722) amyloid beta (A4) precursor protein
  • sheep(101111593) amyloid beta (A4) precursor protein
  • domestic guinea pig(100715302) amyloid beta (A4) precursor protein
  • naked mole-rat(101724743) amyloid beta (A4) precursor protein

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Small Molecule - Antagonist

Product Number
Description
Species
07551
Vanillylidenacetone, ≥98.5%,
Species
human
B9934
BTA-1, ≥98% (HPLC), solid,
Species
human
658960
2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, 97%,
Species
human
C7727
Curcumin, ≥94% (curcuminoid content), ≥80% (Curcumin),
Species
human
C1386
Curcumin, from Curcuma longa (Turmeric), powder,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
SAB2100136
Anti-APP (ab3) antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
immunohistochemistry
western blot
SAB5200113
Anti-APP antibody produced in rabbit, 1 mg/mL, affinity isolated antibody,
Species Reactivity
eukaryotes, human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
SAB4200535
Anti-APP antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
immunoprecipitation (IP)
SAB4300464
Anti-APP (Ab-668) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
western blot
SAB3500274
Anti-APP antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot

Proteins

Product Number
Description
Species
A2326
Amyloid β-Protein Fragment 40-1, ≥90% (HPLC),
Species
human
A1075
Amyloid β Protein Fragment 1-40, ≥90% (HPLC), powder,
Species
human
A9810
Amyloid β Protein Fragment 1-42, ,
Species
human
A4559
Amyloid β-Protein Fragment 25-35, ≥97% (HPLC),
Species
human
S9564
Amyloid Precursor Protein α, Secreted human, >90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution,
Species
human