DSP
desmoplakin
Synonyms:
DP, DPI, DPII
Species:
Human DSP (1832), Mouse Dsp (109620), Rat Dsp (306871), fruit fly dsp (45846), chicken DSP (420869), cow DSP (514360), Horse DSP (100061514), domestic cat DSP (101098382), dog DSP (488207), Domestic Rabbit DSP (100354434) ...More
UniProtKB ID:
Gene ID:
- Human(1832) Summary: Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]
- Mouse(109620) desmoplakin
- Rat(306871) desmoplakin
- fruit fly(45846) dispersed
- chicken(420869) desmoplakin
- cow(514360) desmoplakin
- Horse(100061514) desmoplakin
- domestic cat(101098382) desmoplakin
- dog(488207) desmoplakin
- Domestic Rabbit(100354434) desmoplakin
- sheep(101119169) desmoplakin
- naked mole-rat(101708187) desmoplakin
- domestic guinea pig(100721053) desmoplakin
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