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Merck

PRKAB1

protein kinase, AMP-activated, beta 1 non-catalytic subunit

Synonyms:
AMPK, HAMPKb
Species:
Human PRKAB1 (5564), Mouse Prkab1 (19079), Rat Prkab1 (83803), Horse PRKAB1 (100034094), sheep PRKAB1 (101107899), chicken PRKAB1 (416986), domestic cat PRKAB1 (101094051), naked mole-rat Prkab1 (101705863), cow PRKAB1 (534107), domestic guinea pig Prkab1 (100719458)
UniProtKB ID:
Q9Y478, Q9UBV0, Q9UE20, Q9UEX2, Q9Y6V8
Gene ID:
  • Human(5564) Summary: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]
  • Mouse(19079) protein kinase, AMP-activated, beta 1 non-catalytic subunit
  • Rat(83803) protein kinase, AMP-activated, beta 1 non-catalytic subunit
  • Horse(100034094) protein kinase, AMP-activated, beta 1 non-catalytic subunit
  • sheep(101107899) protein kinase, AMP-activated, beta 1 non-catalytic subunit
  • chicken(416986) protein kinase, AMP-activated, beta 1 non-catalytic subunit
  • domestic cat(101094051) protein kinase, AMP-activated, beta 1 non-catalytic subunit
  • naked mole-rat(101705863) protein kinase, AMP-activated, beta 1 non-catalytic subunit
  • cow(534107) protein kinase, AMP-activated, beta 1 non-catalytic subunit
  • domestic guinea pig(100719458) protein kinase, AMP-activated, beta 1 non-catalytic subunit
  • dog(486295) protein kinase, AMP-activated, beta 1 non-catalytic subunit

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB4503856
Anti-phospho-AMPK β1 (pSer181) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot

Proteins

Product Number
Description
Species
A1233
AMPK (α1/β1/γ1), active, His tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
A1733
AMPK (α2/β1/γ1), active, His tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human