All Photos(1)



Lidocaine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Lidocaine hydrochloride monohydrate, 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide hydrochloride monohydrate, Lignocaine hydrochloride monohydrate, Xylocaine hydrochloride monohydrate
Empirical Formula (Hill Notation):
C14H22N2O · HCl · H2O
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:


certified reference material
pharmaceutical secondary standard

Quality Level


traceable to BP 214
traceable to Ph. Eur. L0600000
traceable to USP 1366013


current certificate can be downloaded


HPLC: suitable
gas chromatography (GC): suitable


pharmaceutical (small molecule)



storage temp.


SMILES string




InChI key


Looking for similar products? Visit Product Comparison Guide

General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Lidocaine hydrochloride is an amide type local anaesthetic that belongs to the class of 1b antiarrhythmics. It is used for regional nerve blocks and infiltrative administration of anaesthesia. It prevents the entry of sodium ions into nerve endings, at the site of pain, and disrupts the electrical signal from reaching the brain.[1]


This pharmaceutical secondary standard can also be used as follows:
  • Sensitive determination of lidocaine hydrochloride and cetylpyridinium chloride in their binary mixtures in different pharmaceutical formulations by three spectrophotometric-based methods
  • Simultaneous analysis of aminoacridine hydrochloride and lidocaine hydrochloride in bulk powder and pharmaceutical formulation by high-performance liquid chromatography (HPLC) and thin-layer chromatography (TLC)-densitometric methods[1]
  • Quantification of ceftriaxone sodium and lidocaine HCl in human plasma samples by high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS)
  • Quantitative analysis of lidocaine hydrochloride and miramistin in a wound healing gel sample by high-performance liquid chromatography (HPLC) combined with UV detection[2]
  • Development of a method based on liquid–liquid extraction of nifedipine and lidocaine hydrochloride from human plasma samples for their subsequent analysis by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)
  • Dispersive liquid-liquid microextraction (DLLME) followed by attenuated total reflectance-Fourier transform infrared measurement of dry films for the determination of lidocaine hydrochloride in human urine sample[3]

Biochem/physiol Actions

Na+ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.


To see an example of a Certificate of Analysis for this material enter LRAB3669 in the slot below. This is an example certificate only and may not be the lot that you receive.


Skull and crossbones

Signal Word


Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More Documents

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service