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Nickel(II) chloride hexahydrate

BioReagent, suitable for cell culture

Linear Formula:
NiCl2 · 6H2O
CAS Number:
Molecular Weight:
MDL number:
PubChem Substance ID:

Quality Level

product line





cell culture | mammalian: suitable

SMILES string




InChI key


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Nickel(II) chloride hexahydrate has been used:
  • in the preparation of nickel platting solution for galvanostatically coating nickel inside the reduced carbon layer during the synthesis of multiwall carbon nanotube micromotors
  • in screening of metals for inflammatory effect on vascular endothelial cells
  • as an additive in artificial cerebrospinal fluid (ACSF) to analyse excitatory post synaptic currents (EPSPs) in the hippocampus slices


100, 500 g in glass bottle

Biochem/physiol Actions

Nickel (Ni) is an essential trace element that plays an important role in the structure and function of DNA, RNA and protein. It has toxic effects on renal, pulmonary and cardiovascular system at higher concentrations. Nickel is implicated in carcinogenesis. Ni2+ ions is a clastogenic agent. Nickel ions (Ni2+) is a non-specific voltage-gated calcium channel blocker.

Signal Word


Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A Inhalation - Muta. 2 - Repr. 1B - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 1 Inhalation

Target Organs


Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Surfactant-Free beta-Galactosidase Micromotors for ?On-The-Move? Lactose Hydrolysis
Maria-Hormigos R, et al.
Advances in Functional Materials, 28(25), 1704256-1704256 (2018)
Functional coupling of Cav2.3 and BK potassium channels regulates action potential repolarization and short-term plasticity in the mouse hippocampus
Gutzmann JJ, et al.
Frontiers in Cellular Neuroscience, 13(3), 492-499 (2019)
Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium
Salnikow K and Zhitkovich A
Chemical Research in Toxicology, 21(1), 28-44 (2007)
Nonrandom chromosomal alterations in nickel-transformed Chinese hamster embryo cells
Conway K and Costa M
Cancer Research, 49(21), 6032-6038 (1989)
Studies on the genotoxic effect of nickel chloride in mice and the possible protective role of soybean seeds extracts
Fahmy MA, et al.
Global Journal of Pharmacology, 8(4), 625-634 (2014)

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