Bridge the gap between two scientific disciplines and advance your research with our best-in-class chemical biology tools and products.
Form the bonds between chemistry and biology.
We offer crosslinkers that vary in length, solubility and functional group reactivity.
We also provide crosslinkers designed for click chemistry reactivity.
As a unique class of functional groups, KATS:
We offer Baran Diversinate crosslinkers with a metal sulfinate on one end to attach directly to otherwise inert C-H bonds and an azide on the other end for attaching to alkynes. We offer various alkyne and strained alkyne crosslinkers for attachment to the azide crosslinker.
Pinpoint your biological target.
With our selection of reactive groups, scaffolds, linkers and tags, you can design probes to include functionalities compatible for:
Choose from probes with high-specificity for one target or subset of a protein to provide insight into biological processes, protein activity and localization, and cell signaling networks.
Probes containing an alkyne, azide or tetrazine handle are paired with bioorthogonally compatible fluorescent or biotinylated tags
Detect cell proliferation especially for in vivo experiments with the EdU nucleoside:
Access a library of molecules from the Dale Boger lab with broad spectrum inhibition of the serine hydrolase family. Tune the compounds to a desired reactivity and selectivity through functional group attachment at an amine site and develop inhibitors to specific subclasses of serine hydrolase enzymes.
Quorum sensing is a chemical communication mechanism used by many common bacteria. New quorum sensing modulators developed by the Helen Blackwell laboratory are some of the most potent inhibitors and activators reported for Gram-negative species.
Accelerate your drug discovery with the DNA-encoded library (DEL) technology, an alternative approach to high-throughput screening (HTS) compound libraries for effective hit and lead discovery.
The fragment DEL from our partner DyNAbind provides an entire screening library in a single tube, making your drug discovery process faster, more effective, and less expensive. We’ve lowered the barriers to DyNAbind DEL technology to provide:
We make ingenuity accessible for you so you can focus on bridging the gap between chemistry and biology. Breakthrough in your work and lead the scientific community into an emerging field backed by our best-in-class solutions and industry leadership.