Stable Isotopes

Applications for Stable Isotopes

The use of our stable isotope-labeled compounds in metabolic and nutritional studies provides a means to dissect biochemical pathways. The availability of isotopically labeled compounds for basic scientific research permits the examination of the role of metabolic pathways in maintaining physiological states. In vivo studies using stable isotope labeled metabolites reveal important aspects of metabolism, including pathways and flux.

An important tool for high-resolution structure determination by NMR spectroscopy is the use of stable isotope-labeled biomolecules. By either selectively or uniformly incorporating stable isotopes into proteins, investigators can reduce the complexity of their spectra significantly. ¹³C, ¹⁵N, and deuterium are the most common isotopes incorporated into proteins through microbial expression systems, peptide synthesis, or with cell-free extracts.

The use of stable isotope compounds in medical imaging, in conjunction with ¹³C-MRS in vivo techniques, provides a method to explore fluxes through energy-related metabolic pathways for early diagnosis and treatment of neuropsychiatric disorders, cancer, and other diseases.

For these and many other applications, we offer a comprehensive portfolio of isotope labeled carbohydrates, amino acids, protected amino acids, metabolites, fatty acids, vitamins, steroids, other biologically-active compounds, and cell culture media and components. We also provide isotopically-labeled synthetic building blocks for researchers who prefer to make their own compounds. With our expertise in isotope synthesis, we stand ready to provide custom compounds for all of your specific needs.

Deuterated Products for Pharmaceuticals and Electronics

With nearly 4,000 isotopically labeled products, we provide unmatched reliability, flexibility, scalability, and support, making us the preferred partner for your needs at any stage of your project from research to production. 

Extensive Labeled Isotope Portfolio and Capacity

From milligram-quantities for drug discovery to metric-ton deliveries for manufacturing, our portfolio includes key products like Methanol-d₄, Iodomethane-d₃, and Benzene-d₆, available in many grades and quantities to suit specific project requirements. Substantial capacity of D₂, D₂O, DMSO- d₆, and many other products are available for projects of any size.

Robust Stable Isotope Supply Chain and Global Presence

We pride ourselves on our secure supply chain, which features capacity redundancy across multiple manufacturing sites and distribution centers around the world. This ensures that you have reliable access to materials, regardless of location. Our partnerships, including a supply contract with the India Heavy Water Board for D₂O, further enhance our ability to deliver high-quality products consistently.

Isotope Customization and CMO Capabilities

We understand every project is unique. Our dedicated technical support team is here to assist you in customizing specifications and documentation to meet your exact needs from research materials to GMP. With strong global R&D teams with extensive process scale-up expertise, we can take your pharmaceutical intermediate or electronic precursor from bench to batch.

Expansion of infrastructure for key stable isotopes

We are committed to advancing the stable isotope availability for diagnostic, industrial and research applications. We recently built out our stable isotope center of excellence to increase production capacity by 50%, the GMP-grade urea-13C Active Pharmaceutical Ingredient (API) used by Urea-13C Breath Test (UBT) kit manufacturers to detect bacteria related to stomach disease.