Concise total synthesis of (+/-)-aspidospermidine via an oxidative Hosomi-Sakurai process.

Concise total synthesis of (+/-)-aspidospermidine via an oxidative Hosomi-Sakurai process.

Chemical communications (Cambridge, England) (2009-05-14)

Cyrille Sabot, Kimiaka C Guérard, Sylvain Canesi

PMID19436917

ABSTRACT

A concise total synthesis of (+/-)-aspidospermidine has been achieved in twelve steps from inexpensive 4-ethylphenol, based on an oxidative Hosomi-Sakurai reaction via the concept of "aromatic ring umpolung".

MATERIALS

Product Number

Brand

Product Description

36724

Supelco

4-Ethylphenol, PESTANAL^®, analytical standard

Pricing and availability is not currently available.

04700

Sigma-Aldrich

4-Ethylphenol, ≥97.0% (GC)

Pricing and availability is not currently available.

W315605

Sigma-Aldrich

4-Ethylphenol, ≥98%, FG

Pricing and availability is not currently available.

E44205

Sigma-Aldrich

4-Ethylphenol, 99%

Pricing and availability is not currently available.