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Alcohol and oral squamous cell carcinoma.

SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging (2013-08-27)
L Feller, R Chandran, R A G Khammissa, R Meyerov, J Lemmer
PMID23971298
ABSTRACT

Alcohol is a risk factor for oral squamous cell carcinoma. It enhances the permeability of the oral epithelium, acts as a solvent for tobacco carcinogens, induces basal-cell proliferation, and generates free radicals and acetaldehyde, which have the capacity to cause DNA damage. Alcohol-associated malnutrition and immune suppression may further promote carcinogenesis. However, acetaldehyde, the first metabolite of ethanol, is the critical agent by which prolonged and excessive consumption of alcoholic beverages increases the risk of oral squamous cell carcinoma. Alcohol also acts synergistically with the products of tobacco combustion in the pathogenesis of oral squamous cell carcinoma.

MATERIALS
Product Number
Brand
Product Description
PHR1070
Supelco
Dehydrated Alcohol, Pharmaceutical Secondary Standard; Certified Reference Material
W200379
Sigma-Aldrich
Acetaldehyde solution, 40 wt. % in H2O
277649
Sigma-Aldrich
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362808
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Ethanol Fixative 80% v/v, suitable for fixing solution (blood films)
676829
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Ethanol standards 10% (v/v), 10 % (v/v) in H2O, analytical standard
719099
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E-053
Supelco
Ethanol-500, 500 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
E-056
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Ethanol-20 (10 ampules/kit), 20 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
270741
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Ethanol-300, 300 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
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Ethanol-80, 80 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
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Ethanol-100 (10 ampules/kit), 100 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
E-032
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