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  • Conversion of pyridine to imidazo[1,2-a]pyridines by copper-catalyzed aerobic dehydrogenative cyclization with oxime esters.

Conversion of pyridine to imidazo[1,2-a]pyridines by copper-catalyzed aerobic dehydrogenative cyclization with oxime esters.

Organic letters (2013-11-23)
Huawen Huang, Xiaochen Ji, Xiaodong Tang, Min Zhang, Xianwei Li, Huanfeng Jiang
ABSTRACT

A rapid and environmentally friendly conversion of pyridine to imidazo[1,2-a]pyridines has been developed via copper-catalyzed aerobic dehydrogenative cyclization with ketone oxime esters.

MATERIALS
Product Number
Brand
Product Description

Supelco
Copper (impurities), manufactured by MBH Analytical Ltd (39X 17868)
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Sigma-Aldrich
Copper, wire, diam. 1.0 mm, ≥99.9%
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Supelco
Pyridine solution, certified reference material, 2000 μg/mL in methanol
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Pyridine hydrochloride, purum, ≥98.0% (AT)
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