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Merck

C6241

Charcoal, Dextran Coated

Synonym(s):

Dextran coated charcoal

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5 G

R 1,691.48

20 G

R 5,085.22

R 1,691.48

List PriceR 1,726.00
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About This Item

UNSPSC Code:
12141908
EC Number:
231-153-3
NACRES:
NC.07

Key Documents

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form

powder

Quality Level

200

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This Item
80485161551C9157
Charcoal, Dextran Coated

Sigma-Aldrich

C6241

Charcoal, Dextran Coated

Activated charcoal for the determination of AOX, 50-150 μm particle size

Supelco

80485

Activated charcoal

Activated charcoal powder, -100 particle size (mesh), decolorizing

Sigma-Aldrich

161551

Activated charcoal

Activated charcoal suitable for cell culture, suitable for plant cell culture

Sigma-Aldrich

C9157

Activated charcoal

form

powder

form

powder

form

powder

form

powder

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

200

Application

Charcoal, Dextran Coated has been used:
  • as a supplement in cell culture media to test the functioning of androgen receptor[1]
  • in the procedure of melatonin radioimmunoassay[2]
  • for the preparation of steroid-free human serum[3]
  • to reduce the creatinine level in untreated serum.

Biochem/physiol Actions

The use of dextran-coated charcoal makes the immunoassay of insulin in biological fluids simpler and more rapid. In theory, the charcoal coated with dextran will adsorb the free hormone and leave hormones that are bound to a carrier (or antibody). Dextran coated charcoal is used to strip hormones from serum instead of charcoal alone, because there is less loss of protein using dextran coated charcoal.[4][5]

General description

Charcoal, Dextran Coated is made from acid washed charcoal powder and dextran, molecular weight 64-76kDa, combined in a 10:1 (w/w) ratio.

Other Notes

Dry preparation of dextran-treated charcoal

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000517277
0000517277
0000505367
0000505367
0000480225

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Liang Shi et al.
Cell death & disease, 8(11), e3171-e3171 (2017-11-17)
Hepatocellular carcinoma (HCC) is a heterogeneous malignancy as a result of complex genetic and epigenetic alterations. HCC is characterized by a clear gender disparity for which there is lack of a clear mechanistic understanding. Androgen receptor (AR) is thought to
Multisteroid LC-MS/MS assay for glucocorticoids and androgens, and its application in Addison's disease.
Methlie P
Endocrine Connections (2013)
Shih-Hsing Leir et al.
Cell and tissue research, 381(2), 327-336 (2020-05-08)
Organoid cultures derived from primary human tissues facilitate the study of disease processes and the development of new therapeutics. Most men with cystic fibrosis (CF) are infertile due to defects in the epididymis and vas deferens; however, the causative mechanisms
Coated charcoal immunoassay of insulin.
Herbert V
The Journal of Clinical Endocrinology and Metabolism, 25, 1375-1384 (1965)
Modern Methods of Steroid Analysis (2012)
View All Related Papers

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. Any data that supports using dextran-coated charcoal to Separate Antibody Complexes from Free Ligand?

    1 answer

    1. In-house data has not been gathered. However, researchers have published relevant studies on this topic. The cited article may serve as a valuable starting point: Binoux MA, Odell WD. "Use of dextran coated charcoal to separate antibody-bound from free hormone: a critique." J Clin Endocrinol Metab. 1973 Feb;36(2):303-10. doi: 10.1210/jcem-36-2-303. PMID: 4734207.

      Helpful?

  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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