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Merck

Viral Clearance

A blue and silver industrial device for large-scale virus filtration with a digital display

Viral safety is a critical aspect of biologics production and relies on the principles of "prevent, detect and remove" to assure viral safety of drugs for patients. Preventing contamination of upstream cell culture processes relies on sourcing and testing raw materials and different technologies to remove viral contaminants. Downstream purification includes steps that either remove or inactivate viruses to provide the clearance required to assure viral safety. 

Our viral clearance portfolio includes the virus filtration solutions, chemicals, holders and systems you need to assure reliable viral safety for your production process. 

Graphic of Virus Inactivation: A: Heat Inactivation; B: Low pH Treatment; C: Detergent Treatment

Virus Inactivation

Enhance biopharma safety and compliance with our virus inactivation solutions, including pasteurization and low pH treatment.

Integrity Testers

Efficient Filter Integrity Testing: Elevate quality control with Integritest® 5, offering bubble point, diffusion, and hydrophobic testing in-line or offline.

Integritest® 5 integrity tester

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Viresolve® Barrier capsules and Viresolve® Pro Devices used to assure viral safety in cell culture media and downstream processing
Virus Filters

Viral safety is a key component of drug safety for patients. Learn how virus filtration reduces risk, assures viral clearance, and enhances viral safety.

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The Mobius® FlexReady solution for large-scale virus filtration
Virus Filter Holders and Systems

Flexible, easy-to-use filter holders are a key component for integration of the Viresolve® Pro Solution, enabling scalable virus filtration that meets your manufacturing demands.

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filters (6)

salts (6)

antioxidants (4)

cables (4)

detergents (4)

surfactants (4)

polyethersulfone (7)

PVDF (6)

mixed cellulose esters (MCE) (6)

silicone (6)

cellulose fiber (5)

TPE (3)

EMPROVE<SUP>&#174;</SUP> EXPERT (10)

EMPROVE<SUP>&#174;</SUP> Filter (6)

EMPROVE<SUP>&#174;</SUP> ESSENTIAL (3)

EMPROVE<SUP>&#174;</SUP> EVOLVE (1)
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TWEEN<SUP>®</SUP> 80 (Polysorbate)
8.17061

TWEEN® 80 (Polysorbate)

EMPROVE® ESSENTIAL, Ph. Eur., JP, NF

tri-Sodium citrate dihydrate
1.06432

tri-Sodium citrate dihydrate

crystalline, EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, USP, E 331

Sodium acetate trihydrate
1.06265

Sodium acetate trihydrate

extra pure, EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, USP, FCC, E 262

tri-Sodium citrate dihydrate
1.06447

tri-Sodium citrate dihydrate

EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP, ACS, E 331

Integritest<SUP>®</SUP> 5 Filter Integrity Test Instrument
IT5INS001

Integritest® 5 Filter Integrity Test Instrument

Viresolve<SUP>®</SUP> ProDevice Modus 1.3
VPMD103NB1

Viresolve® Pro Device

Parvovirus removal filter, Modus 1.3 format, filtration area 0.22 m²

Deviron<SUP>®</SUP> 13-S9
1.08694

Deviron® 13-S9

Detergent, EMPROVE® EXPERT

Sodium acetate trihydrate
1.28205

Sodium acetate trihydrate

EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

Acetic acid
1.37000

Acetic acid

100%, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

Citric acid monohydrate
1.37003

Citric acid monohydrate

crystalline, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

Viresolve<SUP>®</SUP> Pro Device Modus 1.2
VPMD102NB1

Viresolve® Pro Device

Parvovirus removal filter, Modus 1.2 format, filtration area 0.07 m²

Polysorbate 80
1.37171

Polysorbate 80

high purity, EMPROVE® EXPERT, Ph. Eur., ChP, JP, NF

Deviron<SUP>®</SUP> C16
108693

Deviron® C16

Detergent 30% solution, EMPROVE® EVOLVE

Citric acid
1.37002

Citric acid

anhydrous powder, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

Sodium acetate anhydrous
1.28202

Sodium acetate anhydrous

EMPROVE® EXPERT, ChP, USP

Viresolve<SUP>®</SUP> Pro Device Magnus 2.2
VPMG202NB1

Viresolve® Pro Device

Parvovirus removal filter, Magnus 2.2 format, filtration area 1.53 m²

Viresolve<SUP>®</SUP> ProDevice Magnus 2.1
VPMG201NB1

Viresolve® Pro Device

Parvovirus removal filter, Magnus 2.1 format, filtration area 0.51 m²

Tri-n-butyl phosphate
1.00002

Tri-n-butyl phosphate

EMPROVE® EXPERT, Ph. Eur.

Viresolve<SUP>®</SUP> Pro Device Modus 1.1
VPMD101NB1

Viresolve® Pro Device

Parvovirus removal filter, Modus 1.1 format, filtration area 0.017 m²

Sodium caprylate
8.17081

Sodium caprylate

EMPROVE® EXPERT, Ph. Eur., ChP, NF

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