Chiral Mobile Phase Additives

It is possible to effect an enantiomeric separation using conventional HPLC and CE stationary phases by adding a chiral selector to the mobile phase. Chiral selector additives generally interact via ion pair, ligand exchange, or inclusion interactions with enantiomer analytes, forming mobile diastereomeric complexes that are separable by conventional normal phase or reversed-phase columns.
When free cyclodextrins are added to the mobile phase, inclusion complexes are formed and separations can approach those obtained on cyclodextrin-based chiral stationary phases (CSPs). Note - this approach often leads to a reversal in the elution order obtained on a cyclodextrin CSP.
Sigma-Aldrich carries a number of high-purity cyclodextrin derivatives for this application.

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21872 (2-Carboxyethyl)-β-cyclodextrin sodium salt
21906 Carboxymethyl-β-cyclodextrin sodium salt
856088 β-Cyclodextrin hydrate 99%
861413 γ-Cyclodextrin hydrate
494542 α-Cyclodextrin, sulfated sodium salt hydrate
389153 β-Cyclodextrin, sulfated sodium salt extent of labeling: 12-15 mol per mol β-CD
H0513 Heptakis(2,6-di-O-methyl)-β-cyclodextrin
39915 Heptakis(2,6-di-O-methyl)-β-cyclodextrin ≥98.0% (TLC)
51707 Heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin ≥98.0%
H4645 Heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin ≥90%
389137 (2-Hydroxyethyl)-β-cyclodextrin extent of labeling: ~0.7 mol per mol cellulose
390690 (2-Hydroxypropyl)-α-cyclodextrin average Mw ~1,180
332607 (2-Hydroxypropyl)-β-cyclodextrin average Mw ~1,460
332593 (2-Hydroxypropyl)-β-cyclodextrin average Mw ~1,380
389145 (2-Hydroxypropyl)-β-cyclodextrin average Mw ~1,540
56332 (2-Hydroxypropyl)-β-cyclodextrin Mr ~1380
H125 (2-Hydroxypropyl)-γ-cyclodextrin solid
390704 (2-Hydroxypropyl)-γ-cyclodextrin extent of labeling: 0.6 molar substitution
332615 Methyl-β-cyclodextrin average Mn 1310
85990 Succinyl-β-cyclodextrin
332623 Triacetyl-β-cyclodextrin