LC-MS Mobile Phase Additives

It is common practice in LC-MS to add certain chemicals to the mobile phase or introduce them post-column prior to the interface to influence analyte ionization in order to improve the analyte signal. However, some additives may be used to suppress unwanted signals or selectively enhance the signal of particular compounds in a mixture, for example glycosidic species in a mixture of peptides. Sigma-Aldrich offers a wide range of high purity additives for LC-MS applications including the most commonly used acids, bases, volatile salts and sodium source. All are of high purity and tested for LC-MS applications.

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5.33001 Acetic acid 100% for LC-MS LiChropur®  
5.33003 Ammonia solution 25% for LC-MS LiChropur®  
5.33004 Ammonium acetate for LC-MS LiChropur®  
73594 Ammonium acetate for mass spectrometry, LiChropur, eluent additive for LC-MS 99
70221 Ammonium formate eluent additive for LC-MS, LiChropur, ≥99.0% 99
5.33005 Ammonium hydrogen carbonate for LC-MS LiChropur®  
73345 Dibutylammonium acetate solution 0.5 M in H2O, LiChropur, for ion pair chromatography  
00922 Difluoroacetic acid for LC-MS LiChropur, ≥97.5% (GC) New 97.5, 102.5
93645 Dihexylammonium acetate solution 0.5 M in H2O, for ion pair chromatography, LiChropur  
89789 Dipropylammonium acetate solution 0.5 M in H2O, for ion pair chromatography  
5.33002 Formic acid 98% - 100% for LC-MS LiChropur®  
93535 N-(Propionyloxy)succinimide for LC-MS derivatization, LiChropur, ≥95% (HPLC) 95
51197 Sodium formate solution suitable for LC-MS, LiChropur  
80457 Trifluoroacetic acid eluent additive for LC-MS, LiChropur, ≥99.0% (GC) New 99
18370 2,2,2-Trifluoroethanol eluent additive for LC-MS, ≥99.8% (GC) 99.8