Vitamins

Vitamins including isoforms of A, B, C, D, E and K as well as cofactors such as Coenzyme Q10 play vital functions in cellular metabolism from lipid, hormone, and enzyme production to intra- and extracellular transport and gene expression. Deficiencies in vitamins can lead to the development of chronic diseases such as anemia, cardiovascular disease, and cancer. Clinical screening of vitamins or their metabolic analogs by HPLC or LC-MS/MS is routinely performed to assess potential vitamin deficiencies in neonates, pregnant women, and the elderly as well as among adult men and women. The US Food and Drug Administration (FDA) requires manufacturers of vitamin dietary supplements to establish an identity specification for each component used in the manufacturing of dietary supplements. The main methods currently used for vitamin dietary supplement testing include TLC, HPTLC, and HPLC. The use of LC-MS/MS methods for food and dietary supplement testing has increased due to its high sensitivity and throughput, reduction in sample treatment steps compared with other techniques such as GC/MS, and its lower limits of quantitation. The development of analytical methods for vitamins can be challenging due to the sensitivity many vitamins have to air, light and solution pH. Water-soluble vitamins such as riboflavin and vitamin B6, for example, degrade rapidly when exposed to light, and exhibit varying degrees of sensitivity to solution pH. These vitamin specific challenges, if unaddressed during method development, have the potential to reduce the accuracy and precision of the end use testing application.

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V-038 L-Ascorbic acid solution 1.0 mg/mL in acetonitrile: water, certified reference material, Cerilliant®
V-047 L-Ascorbic Acid (Vitamin C)-13C6 solution 500 μg/mL in acetonitrile: water, certified reference material, ampule of 1 mL, Cerilliant®
V-058   beta-Carotene solution 100 μg/mL (THF:Ethanol with 0.1% BHT (70:30) (w/v)), certified reference material, ampule of 1 mL, Cerilliant®
V-059   beta-Carotene(10,10′,11, 11′)-13C4 solution 100 μg/mL (70:30 THF:Ethanol with 0.1% BHT (w/v)), certified reference material, ampule of 1 mL, Cerilliant®
V-060 Coenzyme Q10 solution 1 mg/mL in ethanol, certified reference material, ampule of 1 mL, Cerilliant®
V-019 Cyanocobalamin (Vitamin B12) solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
H-090 1α,25-Dihydroxyvitamin D2 solution 5 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®
H-089 1α,25-Dihydroxyvitamin D3 solution 5 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®
H-107 1,25-Dihydroxyvitamin D3-13C3 (25,26,27-13C3) solution 5 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®
V-046 (±)-gamma-Tocopherol-D3 solution 500 μg/mL in methanol, certified reference material, ampule of 1 mL
E-086 3-epi-25-Hydroxyvitamin D3 solution 50 μg/mL in ethanol, certified reference material, Cerilliant®
H-073 25-Hydroxyvitamin D2 solution 50 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®
H-087 25-Hydroxyvitamin D2 solution 5 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®
H-074 D6-25-Hydroxyvitamin D3 (26,26,26,27,27,27-D6) solution 50 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®
H-083 25-Hydroxyvitamin D3 solution 100 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®
H-086 25-Hydroxyvitamin D3 solution 5 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®
V-034 Nicotinamide-13C6 solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
V-016 Nicotinamide (Vitamin B3) solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
V-035   Nicotinic acid-13C6 solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
V-062 Pantothenic acid hemicalcium salt solution 1.0 mg/mL (90:10 Methanol:Water, (as free acid)), certified reference material, ampule of 1 mL, Cerilliant®
V-063 Pantothenic acid-13C3,15N hemicalcium salt solution 100 μg/mL (90:10 Methanol:Water, (as free acid)), certified reference material, ampule of 1 mL, Cerilliant®
V-069 Pyridoxal 5′-phosphate solution 500 μg/mL (80:20 Water:Acetonitrile), certified reference material, ampule of 1 mL, Cerilliant®
V-011 Retinol solution 100 μg/mL ± 25% (Refer to COA) (Ethanol with 0.1% (w/v) BHT), ampule of 1 mL, reference material, Cerilliant®
V-040 Retinyl acetate solution 100 μg/mL in ethanol (with 0.1% (w/v) BHT; degassed), reference material, Cerilliant®
V-012 Retinyl palmitate solution 100 μg/mL (Ethanol with 0.1% (w/v) BHT), ampule of 1 mL, certified reference material, Cerilliant®
V-067 (−)-Riboflavin 100 μg/mL (1% ammonium acetate in 50:50 methanol:water), certified reference material, ampule of 1 mL, Cerilliant®
V-055 (-)-Riboflavin-13C4,15N2 (Vitamin B2-13C4,15N2) solution 100 μg/mL (1% ammonium acetate in 50:50 methanol:water), certified reference material, ampule of 1 mL, Cerilliant®
V-014 Thiamine HCl (Vitamin B1) solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
V-053   Thiamine pyrophosphate (Vitamin B1 pyrophosphate) solution 1 mg/mL (50:50 Methanol:Water), certified reference material, ampule of 1 mL, Cerilliant®
V-052 Thiamine-13C3 (Vitamin B1-13C3) hydrochloride solution 100 μg/mL in methanol (as free base), certified reference material, ampule of 1 mL, Cerilliant®
V-010 (±)-α-Tocopherol-D6 (Vitamin E-D6) solution 500 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
V-020 (±)−α−Tocopherol (Vitamin E) solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
V-021 (+)-γ−Tocopherol (Vitamin E) solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
V-033   Tocopheryl acetate (Vitamin E acetate) solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
V-024 Vitamin D2 solution 1 mg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®
V-026 D3-Vitamin D2 (6,19,19-D3) solution 100 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®
V-025 Vitamin D3 solution 1 mg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®
V-030 Vitamin K1 solution 10 μg/mL in ethanol, certified reference material, Cerilliant®
V-041 Vitamin K1-13C6 solution 5 μg/mL in ethanol, certified reference material, ampule of 1 mL, Cerilliant®
V-031 Vitamin K2 (MK-4) solution 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
V-042 Vitamin K2 (MK-4)-13C6 solution 10 μg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant®
V-044 Vitamin K2-(MK-7) 100 μg/mL in acetonitrile, certified reference material, Cerilliant®