Immunosuppressants

Immunosuppressants or immunosuppressive drugs inhibit or prevent activity of the immune system. Worldwide, the number of organ transplants performed each year continues to increase. Immunosuppressants assist in the long-term survival rates of organ transplant patients by modifying the immune response to minimize rejection of transplanted organs. Clinical testing laboratories play a critical role in supporting long-term survival rates through therapeutic drug monitoring (TDM) of immunosuppressants. TDM assists the physician in maintaining the delicate balance between toxicity and therapeutic levels of immunosuppressant dosing necessary to prevent organ rejection in patients. Many clinical laboratories have adopted LC-MS/MS technology for the quantitation of immunosuppressant levels in patient biological samples due to its improved sensitivity and specificity over immunoassay (IA) techniques. LC-MS/MS immunosuppressant methods offer an additional benefit of eliminating issues with cross reactivity of immunosuppressant metabolites that is common among IA methods.

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