Hallucinogens are psychoactive agents that can alter perception, thought, emotion, and consciousness. From plant-based psychoactive substances, phencyclidine (PCP) derivatives, and tryptamines to lysergic acid diethylamide (LSD), hallucinogens - also known as psychedelics - remain popular drugs of abuse widely prevalent around the world. The demand for hallucinogens has expanded as a result of increased availability over the internet and the emergence of new, synthetic hallucinogens which circumvent drug abuse legislation. Psychoactive hallucinogens including Kratom, Salvia divinorum, khat, PCP and its derivatives produce sedating and anesthetizing effects in addition to distorting the sensory perceptions of users. Synthetic substituted tryptamine analogs such as 5-methoxy-DMT, 5-methoxy-DALT, and 5-methoxy-AMT have also become very popular among drug users partly replacing consumption of classical, naturally occurring hallucinogens.