Antifungals

Antifungals are a class of drugs used for the treatment of invasive and systemic fungal infections. Antifungal drugs are classified into several groups based on their molecular structure or mechanism of action. Major groups include the triazoles consisting of fluconzaole, itraconazole, voriconazole or posaconazole; imidazoles such as ketoconazole; and antimicrobials. As a result of their high toxicity, narrow therapeutic range, and variable bioavailability, antifungals present significant clinical challenges to patients with severely compromised immune systems. Due to these issues, therapeutic drug monitoring (TDM) of antifungal levels is performed by clinical and diagnostic testing laboratories using HPLC or LC-MS/MS to ensure dosing remains within the drug′s therapeutic range. Antifungals are also used as masking agents since they can potentially co-elute with illicit drugs in forensic or sports testing methods. The triazole antifungal fluconazole has been shown to produce false negative test results in GC/MS confirmation of cocaine use.

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46006 Amphotericin B trihydrate VETRANAL, analytical standard
32593 Cambendazole VETRANAL, analytical standard
C0415 Ciclopirox olamine analytical standard
33931 Clioquinol VETRANAL, analytical standard
F-031 Fluconazole solution 2.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
F-035   Fluconazole-13C3 solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
G-023   Griseofulvin solution 2 mg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant®
G-024   Griseofulvin-D3 solution 1 mg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant®
H-110 Hydroxyitraconazole 100 μg/mL in methanol, certified reference material, Cerilliant®
H-111   Hydroxyitraconazole-D4 100 μg/mL in methanol, certified reference material, Cerilliant®
I-040 Isavuconazole-D4 solution 1 mg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant®
I-015   Itraconazole solution 2.0 mg/mL (Methanol with 1% 1M HCl), ampule of 1 mL, certified reference material, Cerilliant®
I-021 Itraconazole-D4 solution 1.0 mg/mL in methanol (with 1% 1M HCl), certified reference material, Cerilliant®
K-004   Ketoconazole solution 2.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
32991 Lanoconazole VETRANAL, analytical standard
32103 Posaconazole VETRANAL, analytical standard
P-103 Posaconazole solution 2.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
P-108 Posaconazole-D4 solution 1.0 mg/mL in methanol, certified reference material, Cerilliant®
32483 Voriconazole VETRANAL, analytical standard
V-032   Voriconazole solution 2.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
V-036   (±)-Voriconazole-D3 solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®