Anticonvulsants / Antiepileptics

Anticonvulsants, or antiepileptics (AEDs), are a structurally diverse category of drugs used for the treatment of partial and generalized seizures and epilepsy. Antiepileptics have also shown therapeutic efficacy in the management of mood disorders, borderline personality disorder and neuropathic pain. Today, second generation antiepileptics such as levetiracetam, gabapentin, pregabalin, rufinamide, retigabine, and lacosamide have largely supplanted first generation antiepileptics such as phenytoin, valproic acid, and barbiturates which have historically been used to treat seizure disorders. In contrast to first generation AEDs, second generation antiepileptics have a wider gap between therapeutic and toxic serum concentrations and exhibit fewer side effects. Since the frequency, intensity, and type of seizure disease vary among patients, therapeutic drug monitoring (TDM) of antiepileptics is performed to optimize drug efficacy while keeping dosages within the therapeutic range. Routine analytical testing of antiepileptics is also useful in assessing compliance, evaluating overdose, and determining drug-drug interactions.

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A-105 N-Acetylretigabine solution 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
B-063 Brivaracetam-D3 solution 100 μg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant®
94496 Carbamazepine analytical standard
C-053 Carbamazepine solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
51754 Carbamazepine-2,3,4,6,7,8,10,11-d8 analytical standard
C-136 Carbamazepine-13C6 solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
C-094 Carbamazepine-D10 solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
C4206 Carbamazepine 10,11-epoxide analytical standard
93203 Carbamazepine 10,11-epoxide analytical standard
C-121 Carbamazepine-10,11-epoxide solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
C-128 Carbamazepine-10,11-epoxide-13C6 solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
30880 10,11-Dihydrocarbamazepine analytical standard
61347 10,11-Dihydro-10-hydroxycarbamazepine analytical standard
D-091 10,11-Dihydro-10-Hydroxycarbamazepine solution 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
D-104 10,11-Dihydro-10-Hydroxycarbamazepine-13C6 solution 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
68459 Ethosuximide analytical standard
F-029 Felbamate solution 2.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
G-021 Gabapentin solution 10 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
G-018 Gabapentin-13C3 solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
G-017 Gabapentin-D10 solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
G-901 Gabapentin-D10 solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
L-029 Lacosamide solution 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
L-027 Lacosamide-13C, D3 solution 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
L-032 Lacosamide-13C, D3 solution 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
L-019 Lamotrigine solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
L-022 Lamotrigine-13C, 15N4 solution 500 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
L-020 Levetiracetam solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
L-023 Levetiracetam-D6 solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
L-031 Levetiracetam-D6 solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
M-229 Methsuximide solution 1 mg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant®
19532 Oxcarbazepine analytical standard
O-025 Oxcarbazepine solution 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
O-039 Oxcarbazepine-13C6 solution 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
P-116 Perampanel-D4 solution 100 μg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant®
P-063 Phenytoin solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
P-067 Phenytoin-D10 solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
P-120 Pregabalin solution 10.0 mg/mL in water, ampule of 1 mL, certified reference material, Cerilliant®
P-066 Pregabalin solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
P-106 Pregabalin-13C3 solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
P-096 Pregabalin-D6 solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
P-072 Pregabalin-D6 solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
P-075 Primidone solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
R-018 Retigabine solution 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
R-019 Retigabine-D4 solution 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
R-023 Rufinamide solution 1.0 mg/mL in acetonitrile: water (9:1), certified reference material, Cerilliant®
T-081 Tiagabine hydrochloride solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
T-082 Tiagabine-D6 hydrochloride solution 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
T-039 Topiramate solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
T-041 Topiramate-D12 solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
T-150 Topiramate-D12 solution 1 mg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant®
T0781 3,5,5,-Trimethyloxazolidine-2,4-dione analytical standard
V-006 Valproic acid solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
V-029 Valproic Acid-D6 solution 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
V-022 Vigabatrin solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Z-005 Zonisamide solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Z-006 Zonisamide-13C6 solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®