ToyoScreen® Process Development Columns

In manufacturing, chromatography unit operations are some of the most critical in the purification of a new recombinant theraputic protein. In many cases two to four chromatographic steps are needed to achieve the desired purity level for the target molecule.
The first part of the development process is the laboratory scale screening and selection of a resin. Due to the diversity in available ligand chemistries and base matrices offered by different vendors (e.g., agarose, methacrylate, styrene/divinylbenzene, etc.) it is prudent at this stage to screen as many resins as possible. A thorough evaluation is a necessity as each target molecule has very different physical and chromatographic properties. Very often a resin that worked in the past for a similar molecule will not work as effectively for the new target molecule.
Historically, resin screening was accomplished by manually packing various bulk resins into small columns requiring a significant investment in time and cost. To improve the efficiency of resin screening experiments, pre-packed ToyoScreen columns containing the most popular Toyopearl resins provide a low cost and convenient alternative for the evaluation of Toyopearl ligand chemistries.

Features & Benefits
  • Pre-packed columns: Easy to set up and screen an entire resin series for a specific chromatographic mode
  • 1mL and 5mL columns: For sample limited applications with up to milligram purifications
  • Cartridge design: Provides low cost, efficient alternative to self packing with bulk resin
  • Easy connections with ÄKTA®, FPLC and HPLC systems: Seamless integration with any platform
  • Offered in mixed or single chemistry in 6-packs: For cost savings in screening or process optimization experiments

Toyoscreen® Accessories

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842196 Adapter, M6 to 10-32, PEEK PEEK, pkg of 1 ea
842197 Adapter, 1/4-28 to 10-32, PEEK PEEK, pkg of 1 ea