Bile acids

Bile acids are important signaling molecules with high relevance for many biological processes, found in the bile of mammals and other vertebrates. Despite their function to allow digestion of dietary fats and oils by acting as a surfactant that emulsifies them into micelles, bile acids also act as steroid hormones having various direct metabolic effects. Primary bile acids are synthesized by the liver, while secondary bile acids result from bacterial actions in the colon. In humans the steroid acids, taurocholic acid, glycocholic acid, taurochenodeoxycholic acid and glycochenodeoxycholic acid are the major bile acids found in bile. Bile acids are involved in the cholesterol metabolism and do have clinical significance in gastroenterology, hepatology, and gastroenterological oncology. The measurement of the total bile acid pool to diagnose liver injury for example is clinical routine. Information on the individual composition of the bile acid pool can furthermore provide important insight into generation and metabolism of bile acids by both the gut microbiome and the liver.

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C-147 Chenodeoxycholic acid-D4 100 μg/mL in methanol, certified reference material, Cerilliant®
U-002 Ursodeoxycholic acid-D4 100 μg/mL in methanol, certified reference material, Cerilliant®