Catecholamines

Catecholamines, or biogenic amines, are monoamine neurotransmitter derived from the amino acid tyrosine. This group of biologically active compounds plays a critical role in physiological functions, such as brain activity, the regulation of body temperature and stomach pH. Catecholamines are important parameters for the diagnosis of several diseases such as pheochromocytoma or other tumors of the nervous system. Epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine are a group of biogenic amines known as catecholamines. They are produced mainly by the chromaffin cells in the medulla of the adrenal gland. Significantly raised levels of catecholamines and their primary metabolites the metanephrines, including metanephrine, normetanephrine and 3-methoxytyramine, are used diagnostically as markers for the presence of a pheochromocytoma in symptomatic patients. Vanillylmandelic acid (VMA) and homovanillic acid (HVA) are end products of catecholamine metabolism. Increased urinary excretion of VMA and HVA is a diagnostic marker for neuroblastoma, one of the most common solid cancers in early childhood. The biogenic amine, serotonin, is an important neurotransmitter in the central nervous system. Several disorders are associated with pathological changes in serotonin concentrations. Serotonin deficiencies are related to disorders such as depression, schizophrenia, and Parkinson′s disease. Serotonin excess on the other hand is attributed to carcinoid tumors. The determination of serotonin or its metabolite 5-hydroxyindoleacetic acid (5-HIAA) is a standard diagnostic test for carcinoid tumors.

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C-111 Catecholamine Metabolites Mix solution 1 mg/mL each component in methanol, ampule of 1 mL, certified reference material, Cerilliant®
C-109 Catecholamine Mix 1 (Epinephrines) solution 1.0 mg/mL each component in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
C-110 Catecholamine Mix 2 (Metanephrines) solution 1.0 mg/mL each component in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
D-081 Dopamine hydrochloride solution 1.0 mg/mL in methanol with 5% 1 M HCl (as free base), ampule of 1 mL, certified reference material, Cerilliant®
D-072 Dopamine-D4 hydrochloride solution 100 μg/mL in methanol with 5% 1 M HCl (as free base), ampule of 1 mL, certified reference material, Cerilliant®
E-077 (±)-Epinephrine-D6 solution 100 μg/mL in methanol with 5% 1 M HCl, ampule of 1 mL, certified reference material, Cerilliant®
H-091 (+\-)-4-Hydroxy-3-methoxymandelic Acid-D3 (ring-D3) solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
H-092 4-Hydroxy-3-methoxyphenyl-D3-acetic-D2 Acid solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
M-148 (±)-Metanephrine-D3 hydrochloride solution 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
M-171 3-Methoxytyramine hydrochloride 1.0 mg/mL in methanol (as free base), certified reference material, Cerilliant®
M-172 3-Methoxytyramine-D4 HCl 100 μg/mL in methanol (as free base), certified reference material, Cerilliant®
N-069 (±)-Norepinephrine-D6 hydrochloride solution 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
N-068 (±)-Normetanephrine-D3 hydrochloride solution 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®