Reagents for Acylation

Acylation, an alternative to silylation, allows the conversion of compounds with active hydrogen such as -OH, -SH, and -NH into esters, thioesters and amines, respectively. A very popular example of this method is the insertion of perfluoracyl groups to enable electron capture detection (ECD). Carbonyl groups adjacent to halogenated carbons enhance the ECD response.
A further benefit of acylation is the formation of fragmentation-directing derivatives for GC/MS analysis. Acylation reagents can be classified into two main groups: fluoro acid anhydrides and fluoracylimidazoles.

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1.11805 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide for gas chromatography. CAS 24589-78-4, molar mass 199.25 g/mol., for gas chromatography
1.12513 Trifluoroacetic anhydride Trifluoroacetic anhydride for gas chromatography. CAS 407-25-0, EC Number 206-982-9, chemical formula (CF₃CO)₂O., for gas chromatography
91204 Acetic anhydride for GC derivatization, LiChropur®, ≥99.0%
33085 Acetic anhydride
33356 BF3 - Methanol 10 % (w/w), pkg of 20 × 1 mL
29245 N1-[3,5-Bis(trifluoromethyl)benzyl]-N1-methylglycinamide hydrochloride for GC derivatization, ≥99.0% (HPLC)
15716 Boron trifluoride-methanol solution ~10% (~1.3 M), for GC derivatization, LiChropur®
77450 2-Bromoacetophenone for GC derivatization, LiChropur®, ≥99.0%
41392 4-Bromophenacyl trifluoromethanesulfonate for HPLC derivatization, LiChropur®, ≥95% (H-NMR/C-NMR)
19667 Butylboronic acid for GC derivatization, LiChropur®, ≥96.0% (T)
33140 Esterate M for derivatization (GC/GC-MS)
91734 Ethyl trifluoromethanesulfonate for GC derivatization, LiChropur®, ≥99.0%
77253 Heptafluorobutyric anhydride for GC derivatization, LiChropur®, ≥99.0%
74382 N-Heptafluorobutyrylimidazole for GC derivatization, LiChropur®, ≥98.5% (GC)
67389 Hexyl chloroformate for GC derivatization, LiChropur®, ≥97.0% (GC)
87472 Hydrogen chloride - 1-butanol solution ~3 M in 1-butanol, for GC derivatization, LiChropur®
54918 (S)-2-Hydroxybutyric acid for chiral derivatization, ≥97.0%
58360 Isobutyric acid puriss. p.a., ≥99.5%
33355 Methanolic HCl 3 M HCl in methanol (3N), for GC derivatization, ampule of 20 × 1 mL
65371 (±)-α-Methoxy-α-trifluoromethylphenylacetic acid for GC derivatization, LiChropur®, ≥97.0% (T)
78268 N-Methyl-bis-heptafluorobutyramide for GC derivatization, LiChropur®, ≥96.0% (GC)
65943 N-Methyl-bis(trifluoroacetamide) for GC derivatization, LiChropur®, ≥99.0% (GC)
02379 2,3,4,5,6-Pentafluorobenzoic anhydride for GC derivatization, ≥98.0%
17281 1-(Pentafluoropropionyl)imidazole for GC derivatization, ≥98.5%
87851 2,2,6,6-Tetramethyl-3,5-heptanedione for GC derivatization, LiChropur®, ≥98.0%
88300 2-Thenoyltrifluoroacetone for spectrophotometric det. of metal ions, ≥99.0%
80521 Trichloroacetyl chloride for GC derivatization, ≥98.5%
91719 Trifluoroacetic anhydride for GC derivatization, LiChropur®, ≥99.0% (GC)