Reagents for Silylation

Silylation is the most widely used derivatization technique. Functional groups that present a problem with gas chromatogaphy detection - hydroxyl, carboxylic acid, amine, thiol, phosphate - can be derivatized by silylation reagents. Silylation involves replacement of the acidic hydrogen with an alkylsilyl group, for example, -SiMe3.
Silylation derivatives are generally less polar, more volatile and thermally more stable. The choice of a silylating reagent is based on its reactivity and selectivity towards the compound, the intended application, the stability of the derivative, and the abundance/nature of reaction byproducts.

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44795 N,O-Bis(tert-butyldimethylsilyl)acetamide for GC derivatization, LiChropur®, ≥98.0% (GC)
89539 N,O-Bis(tert-butyldimethylsilyl)trifluoroacetamide for GC derivatization
14755 Bis(dimethylamino)dimethylsilane for GC derivatization, LiChropur®, ≥95.0% (GC)
15269 N,O-Bis(trimethylsilyl)acetamide for GC derivatization, LiChropur®, ≥98.5% (GC)
15236 N,O-Bis(trimethylsilyl)carbamate ≥98.0% (T)
15235 N,N-Bis(trimethylsilyl)methylamine for GC derivatization, LiChropur®, ≥97.0% (GC)
15222 N,O-Bis(trimethylsilyl)trifluoroacetamide for GC derivatization, LiChropur®, ≥99.0%
15238 N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane for GC derivatization, LiChropur®, contains 1% TMCS, 99% (excluding TMCS)
15209 N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane for GC derivatization, LiChropur®, contains 10% TMCS, 98% (excluding TMCS)
15248 N,N′-Bis(trimethylsilyl)urea purum, ≥98.0% (N)
92337 Bromotrimethylsilane purum, ≥97.0% (AT)
details BSA+TMCS 5:1
15256   BSA+TMCS for GC derivatization, LiChropur®, 93.0-97.0% (GC)
33151   BSA+TMCS+TMSI 3:2:3, pkg of 144 × 0.1 mL
33148   BSTFA + TMCS, 99:1 pkg of 20 × 1 mL
94380 tert-Butyl(chloro)diphenylsilane for GC derivatization, LiChropur®, ≥98.0% (GC)
06735 tert-Butyldimethylsilyl chloride for GC derivatization, LiChropur®, ≥99.0% (GC)
394882 N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide >97%
77626 N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide for GC derivatization, LiChropur®, ≥99.0% (GC)
00942 N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-Butyldimethylchlorosilane for GC derivatization, LiChropur®, ≥95.0% (GC)
375934 N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-Butyldimethylchlorosilane ≥95%
56563 tert-Butyldimethylsilyl trifluoromethanesulfonate for GC derivatization, LiChropur®, ≥98.0% (T)
76750 Chlorodimethyl(pentafluorophenyl)silane for GC derivatization, LiChropur®, ≥95.0%
90383 Chlorotriethylsilane for GC derivatization, LiChropur®, ≥97.0% (GC)
33014   Chlorotrimethylsilane pkg of 100 mL
92360 Chlorotrimethylsilane puriss., ≥99.0% (GC)
89595 Chlorotrimethylsilane for GC derivatization, LiChropur®, ≥99.0% (GC)
08471 Dichlorodimethylsilane solution ~5% in toluene, for GC derivatization, LiChropur®
41663 1,3-Dimethyl-1,1,3,3-tetraphenyldisilazane ≥98.0% (NT)
226289 N,N-Dimethyltrimethylsilylamine 97%
52619 Hexamethyldisilazane for GC derivatization, LiChropur®, ≥99.0% (GC)
01565 Hexamethyldisiloxane for GC derivatization, LiChropur®, ≥98% (GC)
33350-U   HMDS, Derivatization Grade
69480 N-Methyl-N-trimethylsilylacetamide for GC derivatization, LiChropur®, ≥97.0% (GC)
69484 N-Methyl-N-trimethylsilylheptafluorobutyramide for GC derivatization, LiChropur®, ≥90% (GC)
68768 N-Methyl-N-(trimethyl-d9-silyl)trifluoroacetamide for GC derivatization, LiChropur®, ≥94.0% (GC)
69479 N-Methyl-N-(trimethylsilyl)trifluoroacetamide for GC derivatization, LiChropur®, ≥98.5%
50992   N-Methyl-N-trimethylsilyltrifluoroacetamide activated I for GC derivatization, LiChropur®, activated with ethanethiol and ammonium iodide
12245   N-Methyl-N-trimethylsilyltrifluoroacetamide activated I for GC, activated with ethanethiol and ammonium iodide
44156   N-Methyl-N-trimethylsilyltrifluoroacetamide activated II for GC derivatization, LiChropur®, activated with 2-(Trimethylsilyl)ethanethiol
12124 N-Methyl-N-trimethylsilyltrifluoroacetamide activated III for GC derivatization, LiChropur®, activated with imidazole
69478 N-Methyl-N-(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane for GC derivatization, LiChropur®
85431 Silylating mixture I according to Sweeley for GC derivatization, LiChropur®
85435   Silylating mixture II according to Horning for GC derivatization
85432   Silylating mixture II according to Horning for GC derivatization, LiChropur®
85433 Silylating mixture III for GC derivatization, LiChropur®
505846   Silylation Sampler Kit
43340 1,1,3,3-Tetramethyl-1,3-diphenyldisilazane for GC derivatization, LiChropur®
91566 N-(Trimethylsilyl)acetamide for GC derivatization, LiChropur®, ≥98.0% (GC)
394874 1-(Trimethylsilyl)imidazole for GC derivatization, LiChropur®
92718 1-(Trimethylsilyl)imidazole - Pyridine mixture for GC derivatization, LiChropur®
79271 Trimethylsilyl methallylsulfinate for GC derivatization, ≥90.0% (GC)