What's going on at Pittcon 2019?

Dates: March 17–21, 2019

Location: Pennsylvania Convention Center, Philadelphia, PA

Booth Number: 2318/2319

Visit our booth 2318/2319 at Pittcon 2019 in Philadelphia this March and speak to our booth staff about our latest innovations, technical posters and booth activities.
 

 2019 Pittcon Heritage Award

We are honored that the Chemical Heritage Foundation and the Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy have awarded Dr. Walter Supina and Mr. Nicholas Pelick with the 2019 Pittcon Heritage Award. As we are celebrating 350 years of our parent company, we raise our peaks and say here’s to 350 more years of quality analytical products without compromise—made by analytical chemists for analytical chemists.

 50 years exhibition - Changing Lives One Signature at a Time!

“Sign for a Cause” we are celebrating 50 years exhibiting at the Pittsburgh Conference. We invite each of you to sign our card at our booth 2318/2319.

For every signature we will donate $3 to St. Jude’s Children’s Research Hospital.

 Product Introductions at Pittcon 2019

NEW! LiChrosolv® UHPLC-MS Solvents

  • Advanced solvent line for rapid and reliable results
  • Remarkably clean impurity profile
  • Polyethylene glycol (PEG) free
  • Suitable for both ESI/APCI + and - ionization modes
  • Website: sigmaaldrich.com/uhplc-ms

NEW! Selectivities for Ascentis® Express and BIOshell™ HPLC/UHPLC Columns

  • Obtain maximum speed and resolution for small and large molecule separations
  • Ascentis® Express 90Å AQ-C18, and 160Å C30
  • BIOshell™ Peptide 160Å Phenyl Hexyl, IgG 1000Å C18, and IgG 1000Å Diphenyl
  • Websites: sigmaaldrich.com/express and sigmaaldrich.com/bioshell

NEW! Reference Materials for Clinical Testing

  • Fentanyl analogs, estrogens in serum, synthetic cannabinoids, acylcarnitine neats & solution mixes, vitamins, PEth 16:0/18:1, insulin, and IGF-1 proteins
  • Website: sigmaaldrich.com/standards

NEW! MQuant® StripScan (Don’t Guess. Measure!)

  • Analysis tool for your smartphone – no more color guessing!
  • Reliable digital test strip readout, data storage, and visualization
  • Subsequent advanced data analysis possible through a Website app
  • Website: sigmaaldrich.com/mquant-stripscan

NEW! Smart Titration Solutions & Standards (Titration Goes Digital!)

  • Seamless data transfer to titrators via RFID technology
  • Ensures a fast, secure, and time-saving titration process
  • Website: sigmaaldrich.com/titration

NEW! Reference Materials for Food & Beverage Testing

  • Milk proteins, marine toxins, sweeteners & flavoring agents, heavy metal mixes (cannabis testing), PhytoLab global distribution (natural products)
  • Website: sigmaaldrich.com/standards

NEW! HPLC-certified Hydrophilic PTFE Millex® Filters

  • Millex®-LG, LCR filters contain hydrophilic PTFE membranes and are HPLC-certified for low levels of UV-absorbing extractables.
  • Hydrophilic PTFE membranes have broad chemical compatibility, enabling filtration of aqueous and organic solvents.
  • Easy to read membrane type and pore size printed on every Millex® filter.
  • Over-molded design provides excellent seal integrity and burst strength.
  • Website: sigmaaldrich.com/onemillex

NEW! Millicup™-FLEX Disposable Vacuum Filtration Unit

  • Compatible with organic and aqueous solvents
  • Disposable setup reduces the risk of contamination and membrane fouling
  • Compatible with 47 mm membrane filter, customizable to the needs of each filtration
  • Filter directly into GL45 vacuum-rated storage bottles
  • Ergonomic, clampless design

NEW! Milli-Q® IQ 7003/7005 Integrated Ultrapure and Pure Water System

  • Providing superior quality Type 1 and Type 2 water directly from tap water
  • Simple and intuitive Q-POD® and E-POD® dispensers
  • Touchscreen display for unparalleled ease of use
  • Effortless data management and ensured traceability
  • Compact and versatile to optimize lab space
  • Website: emdmillipore.com/h2o

On top of the new innovations we will be presenting at Pittcon, our booth staff is on hand to discuss our entire analytical portfolio - from Lab Water purification systems to chemicals for titration and consumables for chromatography.

 Curiosity Cube

Curious? Breakthrough begins with Curiosity. Visit our Curiosity Cube at booth 419. A retrofitted shipping container that has been transformed into a mobile science lab.

 


 Oral Presentations

 
Title: New Developments on the Selectivity of Ionic Liquid Capillary Columns
Abstract: Ionic liquid stationary phases have been demonstrated to provide very unique selectivity’s compared to traditional polysiloxane or polyethylene glycol based phases. Their selectivity is made possible due to the various combinations of cations and anions that are available along with spacer groups used to prepare these germinal dicationic phases. Columns prepared with di- or tricationic phases and newer phases that contain a PEG or branched chain alkyl linkage chain have the ability to perform many of the same applications as columns made with polysiloxane polymer or polyethylene glycol stationary phases of similar polarity, but with slight elution order changes. Many times this results in increased resolution and/or shorter run times. We are continuing the work on evaluating and developing new ionic liquids stationary phases and new applications with them. This paper will update the recent studies on the selectivity of ionic liquid phases for applications with a variety of different sample types from a number of industries including water analysis, petrochemical, pharmaceutical, environmental, food and beverage and flavor and fragrance.

Presenter: Len Sidisky
Date & Time: Monday, March 18, 2019, 10:25 AM
Location: Room 120C

 

Title: Unique Essential Oil Analyses Using the Selectivity of Ionic Liquid Capillary Columns
Abstract: Flavor and fragrance (essential oils) analyses represent some of the most challenging chromatographic separations, due to the complexity of the various samples. Essential oils are composed of a wide variety of chemical compounds such as terpenes, ketones, aldehydes, alcohols, esters and other hydrocarbons. The complexity of these samples necessitates the use of capillary gas chromatography in order to provide adequate resolution of key compounds in the samples. The best way to improve the resolution of essential oil samples is to choose a capillary column with a unique selectivity. Traditionally, columns based on polysiloxane or polyethylene glycol chemistries have been the columns of choice for these analyses. Over the years, extensive evaluations of columns manufactured with ionic liquid stationary phases have occurred. Their main strength was discovered to be unique selectivity. These columns have the ability to perform many of the same applications as columns made with polysiloxane polymer or polyethylene glycol stationary phases of similar polarity, but with slight elution order changes. Many times this results in increased resolution and/or shorter run times. We have been able to demonstrate very unique separations of key flavor isomers such as farnesol and santalol that can only be achieved on the ionic liquid columns as two examples. This paper will compare and contrast the selectivity of the ionic liquids stationary phases with traditional phases of similar or like selectivity’s for applications with a variety of different essential oil samples.

Presenter: Len Sidisky
Date & Time: Tuesday, March 19, 2019, 2:30 PM
Location: Room 121C

 

Title: Face to Phase: How Antibody Domains Affect Retention on Chromatographic Stationary Phases
Abstract: Biotherapeutics are continuously being manufactured and produced to treat an ever-expanding list of chronic diseases ranging from Alzheimer’s disease to Crohn’s disease.  As the predominant form of these biotherapeutics, monoclonal antibodies (mAbs) are seeing a renaissance in researching not just their modes of action, but in ways of purifying and analyzing them.  mAbs are composed of a heavy chain and a light chain, and have two domains: the antigen-binding domain (Fab) and the fragment crystallizable domain (Fc).  Both of these domains are responsible for a different aspect of an antibody’s mode of action; therefore, these two domains are structurally and chemically different.  This seminar will investigate the roles that these different domains play in retention of an antibody to chromatographic stationary phases.  A series of intact and reduced antibodies will be analyzed by size exclusion chromatography (SEC), hydrophobic interaction chromatography (HIC), and ion exchange chromatography (IEX) in an effort to elucidate which domain of an antibody lends itself to the overall retention of the intact antibody.  The results of these studies will then be used to build a systematic method for gauging and understanding the protein structural factors that play a role in native liquid chromatography (LC) of antibodies.

Presenter: Cory Muraco
Date & Time: Wednesday, March 20, 2019, 8:50 AM
Location: Room 121A

 

Title: Improving Cannabis Testing Workflows  
Abstract: Testing is performed on cannabis and cannabis based products to ensure both quality and safety.  The types of assays conducted often fall into one of two categories;  profiling and contaminant testing.  This presentation will discuss the workflow for several specific types of tests commonly performed on cannabis and some suggested approaches for improving the quality of the testing.  Specifically, potency, pesticide residue and terpene testing will be covered. With regards to potency, optimization of chromatographic conditions and issues related to stability and storage of standards will be discussed. For pesticide testing, a comprehensive approach for using a single extract for both GC and LC analysis will be outlined. Finally, an easy, fast and highly automatable method using SPME for terpene analysis will be presented.

Presenter: Katherine Stenerson
Date & Time: Thursday, March 21, 2019, 10:35 AM
Location: Room 115A

 Technical Posters

 
Title: Titration goes digital – automatic data transfer from titration solutions & standards to the titrator 
Safe and precise titration results will be achieved with a new technology of transferring the data automatically from the reagents and standards to the titrator software. One important step in the titration procedure is the correct transfer of data. Chemical name, concentration, batch number, shelf life, article number, traceability is important for the documentation according to Quality Assurance guidelines and for the calculation of the results. A new generation of titrators with an RFID reader together with smart chemicals coded with an RFID chip will transfer the data automatically. This avoids data transfer failures and makes the titration process faster and easier. All data will be saved and stored in the instrument software and will be used for the calculation of results or gives warning when the shelf life will be expired. Data for audits are available in the titration system software and can be shown immediately. A correct standardization with a titrimetric standard is important for reproducible titration results. The instrument method will tell you which standard is needed and calculate with the correct data delivered through the RFID chip from the standard like molecular weight and assay. After transferring all data, the titration process can start. Precise, accurate and correct titration results will be achieved with a stringent and constant titration process, a precise titer determination, a regular maintenance of the instruments and a correct data transfer. You will learn in this presentation how to improve your titration process and fulfil requirements of QA regulations.

Date & Time: Tuesday, March 19, 2019, Morning (10:00 am - 12:30 pm)
Location: Room Expo Floor, back of aisles 1500-2300

 

Title: Next-generation TOC monitor for ultrapure water purification systems.
As analytical techniques are becoming increasingly sensitive, many researchers rely on TOC monitoring of the ultrapure water they use for their analyses. In water purification systems, TOC monitoring is based on resistivity measurements combined with photo-oxidation of the organic compounds by UV irradiation. The goal of this project was to redesign an existing TOC monitor for greater measurement accuracy and shorter analysis time. The new design was developed along 3 major axes: 1. The commonly used Hg lamp was replaced with a mercury-free excimer lamp. This lamp, through its unique properties, allows the real-time monitoring of the oxidation phase for improved accuracy. In addition, it is more environmentally-friendly than mercury lamps. 2. To increase the accuracy of temperature measurements, a thermal modelization of water and quartz was used to predict complex thermal behavior within the cell and ensure better accuracy than any embedded probe. 3. Combining electronic design with a highly optimized software for resistivity measurement allows for more accurate resistivity measurements. Several end-of-oxidation algorithms, using different temperature compensation methods were tested until the method was optimized. These optimizations were made thanks to a post treatment software to significantly reduce the development time. In conclusion, this new generation TOC monitor, relying on dynamic end-of-oxidation detection and optimized software, greatly improves the accuracy and divides by 3 the time needed for TOC measurements in ultrapure water systems. It allows precise measurements in the 0.5 – 999.9 ppb range, and its precision passes USP and EP suitability tests (error: +/- 1 ppb or +/- 15 %, whichever is greater, and typically +/- 0.4 ppb for less than 5 ppb).

Date & Time: Tuesday, March 19, 2019, Morning (10:00 am - 12:30 pm)
Location: Expo floor, back of aisles 1500-2300

 

Title: Innovative mercury-free UVc-LED reactor for bacteria control in purified water.
The traditional mercury-based UV lamps used for bacteria control in the production of purified water have several drawbacks for integration into lab equipment: large size, fragile, high power consumption and dangerous voltage. Moreover, there are significant environmental concerns regarding mercury. Recent advances in UVc LED technology, mainly in the 265 nm to 285 nm range, opened the door to attractive solutions for bacteria control in ultrapure water. However, short lifetime in continuous running mode, high temperature and low UV power output compared to classical mercury lamps were weaknesses to overcome when designing high performance UVc LED reactors. Optimization of UVc optical reflection, thermal dissipation and control of fluid dynamics were required to develop a solution. Extensive research work and design development have led to an optimal water cooling solution for the UV-LED devices. A significant number of multi-physic simulations and testing on high purity water spiked with bacteria were performed to identify the best final solution. This presentation demonstrates the robustness and high performance of this new mercury-free solution to control bacteria levels in water purification systems.

Date & Time: Tuesday, March 19, 2019, Morning (10:00 am - 12:30 pm)
Location: Expo floor, back of aisles 1500-2300