Human(23305) Summary: The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011]
Mouse(216739) acyl-CoA synthetase long-chain family member 6
Rat(117243) acyl-CoA synthetase long-chain family member 6
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MISSION® siRNAs have been designed using a world-class siRNA design algorithm licensed from Rosetta Inpharmatics, a leader in advanced siRNA research. The Rosetta-powered siRNA design algorithm has been optimized with over 3 years of continuous development for enhanced performance in RNAi applications. New and critical siRNA design rules incorporated into the latest algorithm lead to increased target specificity and knockdown for low abundance messages.
Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
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siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_001009185
Rosetta Predictions
human
pricing
NM_015256
Rosetta Predictions
human
pricing
NM_130739
Rosetta Predictions
rat
pricing
NM_001033597
Rosetta Predictions
mouse
pricing
NM_001033598
Rosetta Predictions
mouse
pricing
NM_001033599
Rosetta Predictions
mouse
pricing
NM_144823
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_015256
ACSL6 MISSION shRNA Bacterial Glycerol Stock acyl-CoA synthetase long-chain family member 6
Human
10 Products Total
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