Human(672) Summary: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]
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MISSION® siRNAs have been designed using a world-class siRNA design algorithm licensed from Rosetta Inpharmatics, a leader in advanced siRNA research. The Rosetta-powered siRNA design algorithm has been optimized with over 3 years of continuous development for enhanced performance in RNAi applications. New and critical siRNA design rules incorporated into the latest algorithm lead to increased target specificity and knockdown for low abundance messages.
Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
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siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_007294
Rosetta Predictions
human
pricing
NM_007295
Rosetta Predictions
human
pricing
NM_007296
Rosetta Predictions
human
pricing
NM_007297
Rosetta Predictions
human
pricing
NM_007298
Rosetta Predictions
human
pricing
NM_007299
Rosetta Predictions
human
pricing
NM_007300
Rosetta Predictions
human
pricing
NM_007302
Rosetta Predictions
human
pricing
NM_007303
Rosetta Predictions
human
pricing
NM_007304
Rosetta Predictions
human
pricing
NM_007305
Rosetta Predictions
human
pricing
NM_012514
Rosetta Predictions
rat
pricing
XM_579334
Rosetta Predictions
rat
pricing
NM_009764
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_009764
VALIDATED
BRCA1 MISSION shRNA Bacterial Glycerol Stock breast cancer 1, early onset
Mouse
10 Products Total
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Price
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