Human(9167) Summary: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. [provided by RefSeq, Jul 2008]
Mouse(20463) cytochrome c oxidase subunit VIIa polypeptide 2-like
Rat(298762) cytochrome c oxidase subunit VIIa polypeptide 2 like
chicken(421392) cytochrome c oxidase subunit VIIa polypeptide 2 like
cow(540225) cytochrome c oxidase subunit VIIa polypeptide 2 like
dog(475739) cytochrome c oxidase subunit VIIa polypeptide 2 like
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siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_004718
Rosetta Predictions
human
pricing
NM_001106704
Rosetta Predictions
rat
pricing
NM_009187
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_009187
VALIDATED
COX7A2L MISSION shRNA Bacterial Glycerol Stock cytochrome c oxidase subunit VIIa polypeptide 2 like
Mouse
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