Human(64421) Summary: This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA). [provided by RefSeq, Jul 2008]
Mouse(227525) DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)
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MISSION® siRNAs have been designed using a world-class siRNA design algorithm licensed from Rosetta Inpharmatics, a leader in advanced siRNA research. The Rosetta-powered siRNA design algorithm has been optimized with over 3 years of continuous development for enhanced performance in RNAi applications. New and critical siRNA design rules incorporated into the latest algorithm lead to increased target specificity and knockdown for low abundance messages.
Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
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siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_001033855
Rosetta Predictions
human
pricing
NM_001033857
Rosetta Predictions
human
pricing
NM_001033858
Rosetta Predictions
human
pricing
NM_022487
Rosetta Predictions
human
pricing
NM_147145
Rosetta Predictions
rat
pricing
NM_001110214
Rosetta Predictions
mouse
pricing
NM_146114
Rosetta Predictions
mouse
pricing
NM_175683
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_146114
DCLRE1C MISSION shRNA Bacterial Glycerol Stock DNA cross-link repair 1C
Mouse
8 Products Total
TRC Number
Price
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