Human(1788) Summary: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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MISSION® siRNAs have been designed using a world-class siRNA design algorithm licensed from Rosetta Inpharmatics, a leader in advanced siRNA research. The Rosetta-powered siRNA design algorithm has been optimized with over 3 years of continuous development for enhanced performance in RNAi applications. New and critical siRNA design rules incorporated into the latest algorithm lead to increased target specificity and knockdown for low abundance messages.
Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
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siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_022552
Rosetta Predictions
human
pricing
NM_153759
Rosetta Predictions
human
pricing
NM_175629
Rosetta Predictions
human
pricing
NM_175630
Rosetta Predictions
human
pricing
NM_001003957
Rosetta Predictions
rat
pricing
NM_001003958
Rosetta Predictions
rat
pricing
NM_007872
Rosetta Predictions
mouse
pricing
NM_153743
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_007872
VALIDATED
DNMT3A MISSION shRNA Bacterial Glycerol Stock DNA (cytosine-5-)-methyltransferase 3 alpha
Mouse
10 Products Total
TRC Number
Price
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