Human(2130) Summary: This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]
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MISSION® siRNAs have been designed using a world-class siRNA design algorithm licensed from Rosetta Inpharmatics, a leader in advanced siRNA research. The Rosetta-powered siRNA design algorithm has been optimized with over 3 years of continuous development for enhanced performance in RNAi applications. New and critical siRNA design rules incorporated into the latest algorithm lead to increased target specificity and knockdown for low abundance messages.
Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
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siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_005243
Rosetta Predictions
human
pricing
NM_013986
Rosetta Predictions
human
pricing
NM_001025632
Rosetta Predictions
rat
pricing
XM_001065285
Rosetta Predictions
rat
pricing
XM_001065346
Rosetta Predictions
rat
pricing
XM_001068194
Rosetta Predictions
rat
pricing
XM_001068285
Rosetta Predictions
rat
pricing
XM_001068438
Rosetta Predictions
rat
pricing
XM_001068487
Rosetta Predictions
rat
pricing
XM_001068534
Rosetta Predictions
rat
pricing
NM_007968
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_007968
EWSR1 MISSION shRNA Bacterial Glycerol Stock EWS RNA-binding protein 1
Mouse
12 Products Total
TRC Number
Price
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