Human(55294) Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
dog(475465) F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Horse(100062294) F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
cow(540932) F-box and WD repeat domain containing 7
domestic cat(101096146) F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
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Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
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siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_001013415
Rosetta Predictions
human
pricing
NM_018315
Rosetta Predictions
human
pricing
NM_033632
Rosetta Predictions
human
pricing
NM_080428
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_080428
VALIDATED
FBXW7 MISSION shRNA Bacterial Glycerol Stock F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Mouse
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