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LGMN

legumain

59 Gene Product Result for
Synonyms: AEP LGMN1 PRSC1
UniProtKB ID: Q99538, O00123, Q9BTY1
Gene ID:
Human(5641) Summary: This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]
Mouse(19141) legumain
Rat(63865) legumain
cow(281281) legumain
dog(480232) legumain
chicken(423418) legumain
sheep(678680) legumain
Custom Gene Products
Our expertise in DNA & RNA oligo design, chemistry and manufacturing enable Sigma Custom Products to provide a comprehensive product portfolio. Learn more about our "custom capabilities & extensive options today."

ELISA

Product # Description Species Add to Cart
 
RAB0708 Human LGMN / Legumain ELISA Kit human pricing

AQUA Peptides

Product # Description Species Add to Cart
 
AQ0906 AQUA Peptide DYTGEDVTPENFLAVL[R] mouse, rat pricing

shRNA

Type Description Species Add to Cart
 

Custom CRISPR Plasmid

Product # Description  
 
CRISPR Custom CRISPR Plasmid for gene knockout

siRNA

siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm.
All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product # siRNA Type Species  
 
NM_001008530 Rosetta Predictions human pricing
NM_005606 Rosetta Predictions human pricing
NM_022226 Rosetta Predictions rat pricing
NM_011175 Rosetta Predictions mouse pricing
siRNA
PRODUCT # siRNA Type ? SPECIES
NM_001008530 Rosetta Predictions Human
Ranking siRNA ID Sequence Start ?
1 SASI_Hs01_00087748 predicted 859
2 SASI_Hs01_00087749 predicted 868
3 SASI_Hs01_00087750 predicted 1517
4 SASI_Hs01_00087751 predicted 1245
5 SASI_Hs01_00087752 predicted 1165
6 SASI_Hs01_00087753 predicted 832
7 SASI_Hs01_00087754 predicted 1143
8 SASI_Hs01_00087755 predicted 594
9 SASI_Hs01_00087756 predicted 1272
10 SASI_Hs01_00087757 predicted 794
siRNA
PRODUCT # siRNA Type ? SPECIES
NM_005606 Rosetta Predictions Human
Ranking siRNA ID Sequence Start ?
1 SASI_Hs01_00103734 predicted 736
2 SASI_Hs01_00103735 predicted 750
3 SASI_Hs01_00103736 predicted 1397
4 SASI_Hs01_00103737 predicted 1129
5 SASI_Hs01_00103738 predicted 1045
6 SASI_Hs01_00103739 predicted 713
7 SASI_Hs01_00103740 predicted 1024
8 SASI_Hs01_00103741 predicted 480
9 SASI_Hs01_00103742 predicted 1154
10 SASI_Hs01_00103743 predicted 673
siRNA
PRODUCT # siRNA Type ? SPECIES
NM_022226 Rosetta Predictions Rat
Ranking siRNA ID Sequence Start ?
1 SASI_Rn01_00100103 predicted 1290
2 SASI_Rn01_00100104 predicted 1019
3 SASI_Rn01_00100105 predicted 375
4 SASI_Rn01_00100106 predicted 1298
5 SASI_Rn01_00100107 predicted 1080
6 SASI_Rn02_00262990 predicted 898
7 SASI_Rn01_00100109 predicted 1416
8 SASI_Rn01_00100110 predicted 311
9 SASI_Rn01_00100111 predicted 534
10 SASI_Rn01_00100112 predicted 369
11 SASI_Rn01_00100108 predicted 1042
siRNA
PRODUCT # siRNA Type ? SPECIES
NM_011175 Rosetta Predictions Mouse
Ranking siRNA ID Sequence Start ?
1 SASI_Mm01_00183992 predicted 1347
2 SASI_Mm01_00183993 predicted 888
3 SASI_Mm01_00183994 predicted 1243
4 SASI_Mm02_00320054 predicted 891
5 SASI_Mm01_00183995 predicted 1323
6 SASI_Mm01_00183997 predicted 425
7 SASI_Mm01_00183998 predicted 204
8 SASI_Mm01_00184000 predicted 602
9 SASI_Mm02_00320055 predicted 738
10 SASI_Mm02_00320056 predicted 1341
11 SASI_Mm01_00183991 predicted 640
12 SASI_Mm01_00183996 predicted 957
13 SASI_Mm01_00183999 predicted 415