Human(23239) Summary: This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]
Mouse(98432) PH domain and leucine rich repeat protein phosphatase 1
Rat(59265) PH domain and leucine rich repeat protein phosphatase 1
chicken(420904) PH domain and leucine rich repeat protein phosphatase 1
Horse(100057142) PH domain and leucine rich repeat protein phosphatase 1
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MISSION® siRNAs have been designed using a world-class siRNA design algorithm licensed from Rosetta Inpharmatics, a leader in advanced siRNA research. The Rosetta-powered siRNA design algorithm has been optimized with over 3 years of continuous development for enhanced performance in RNAi applications. New and critical siRNA design rules incorporated into the latest algorithm lead to increased target specificity and knockdown for low abundance messages.
Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
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siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_194449
Rosetta Predictions
human
pricing
NM_021657
Rosetta Predictions
rat
pricing
XM_001475839
Rosetta Predictions
mouse
pricing
XM_129968
Rosetta Predictions
mouse
pricing
XM_900133
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_194449
VALIDATED
PHLPP1 MISSION shRNA Bacterial Glycerol Stock PH domain and leucine rich repeat protein phosphatase 1
Human
12 Products Total
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Price
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