Human(5277) Summary: This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12. [provided by RefSeq, Jun 2010]
Mouse(18700) phosphatidylinositol glycan anchor biosynthesis, class A
Rat(363464) phosphatidylinositol glycan anchor biosynthesis, class A
Zebrafish(791759) phosphatidylinositol glycan anchor biosynthesis, class A
dog(491748) phosphatidylinositol glycan anchor biosynthesis, class A
Horse(100055827) phosphatidylinositol glycan anchor biosynthesis, class A
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MISSION® siRNAs have been designed using a world-class siRNA design algorithm licensed from Rosetta Inpharmatics, a leader in advanced siRNA research. The Rosetta-powered siRNA design algorithm has been optimized with over 3 years of continuous development for enhanced performance in RNAi applications. New and critical siRNA design rules incorporated into the latest algorithm lead to increased target specificity and knockdown for low abundance messages.
Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
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siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_002641
Rosetta Predictions
human
pricing
NM_020472
Rosetta Predictions
human
pricing
NM_020473
Rosetta Predictions
human
pricing
NM_001108816
Rosetta Predictions
rat
pricing
NM_011081
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_002641
VALIDATED
PIGA MISSION shRNA Bacterial Glycerol Stock phosphatidylinositol glycan anchor biosynthesis, class A
Human
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