PRKACA

Human(5566) Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Mouse(18747) protein kinase, cAMP dependent, catalytic, alpha

Rat(25636) protein kinase, cAMP-dependent, catalytic, alpha

naked mole-rat(101707235) protein kinase, cAMP-dependent, catalytic, alpha

domestic guinea pig(100735694) protein kinase, cAMP-dependent, catalytic, alpha

cow(282322) protein kinase, cAMP-dependent, catalytic, alpha

sheep(443094) protein kinase, cAMP-dependent, catalytic, alpha

Horse(100064302) protein kinase, cAMP-dependent, catalytic, alpha

domestic cat(101090494) protein kinase, cAMP-dependent, catalytic, alpha

dog(403556) protein kinase, cAMP-dependent, catalytic, alpha