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PRKAR2A

protein kinase, cAMP-dependent, regulatory, type II, alpha

149 Gene Product Result for
Synonyms: PKR2 PRKAR2
UniProtKB ID: P13861, Q16823
Gene ID:
Human(5576) Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]
Mouse(19087) protein kinase, cAMP dependent regulatory, type II alpha
Rat(29699) protein kinase, cAMP dependent regulatory, type II alpha
cow(100139910) protein kinase, cAMP-dependent, regulatory, type II, alpha
cow(518399) protein kinase, cAMP-dependent, regulatory, type II, alpha
sheep(101118483) protein kinase, cAMP-dependent, regulatory, type II, alpha
naked mole-rat(101706516) protein kinase, cAMP-dependent, regulatory, type II, alpha
domestic guinea pig(100728915) protein kinase, cAMP-dependent, regulatory, type II, alpha
dog(100685147) protein kinase, cAMP-dependent, regulatory, type II, alpha
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shRNA

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Custom CRISPR Plasmid

Product # Description  
 
CRISPR Custom CRISPR Plasmid for gene knockout

siRNA

siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm.
All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product # siRNA Type Species  
 
NM_004157 siRNAs that have been validated in the lab human pricing
NM_019264 Rosetta Predictions rat pricing
NM_008924 Rosetta Predictions mouse pricing
siRNA
PRODUCT # siRNA Type ? SPECIES
NM_004157 siRNAs that have been validated in the lab Human
Ranking siRNA ID Sequence Start ? Purification Size ? Price Select
1 SASI_Hs01_00122100 validated 1055
2 SASI_Hs02_00337012 predicted 1288
3 SASI_Hs01_00122102 predicted 1063
4 SASI_Hs02_00337013 predicted 1071
5 SASI_Hs01_00122103 predicted 547
6 SASI_Hs01_00122104 predicted 1173
7 SASI_Hs01_00122106 predicted 744
8 SASI_Hs01_00122108 predicted 551
9 SASI_Hs01_00122109 predicted 524
10 SASI_Hs02_00337014 predicted 856
11 SASI_Hs01_00122101 predicted 721
12 SASI_Hs01_00122105 predicted 634
13 SASI_Hs01_00122107 predicted 972
siRNA
PRODUCT # siRNA Type ? SPECIES
NM_019264 Rosetta Predictions Rat
Ranking siRNA ID Sequence Start ? Purification Size ? Price Select
1 SASI_Rn02_00262156 predicted 870
2 SASI_Rn01_00064069 predicted 392
3 SASI_Rn01_00064070 predicted 1262
4 SASI_Rn01_00064071 predicted 718
5 SASI_Rn01_00064072 predicted 540
6 SASI_Rn01_00064073 predicted 1310
7 SASI_Rn01_00064074 predicted 1237
8 SASI_Rn01_00064076 predicted 718
9 SASI_Rn01_00064078 predicted 894
10 SASI_Rn02_00262157 predicted 1073
11 SASI_Rn01_00064075 predicted 507
12 SASI_Rn01_00064077 predicted 382
siRNA
PRODUCT # siRNA Type ? SPECIES
NM_008924 Rosetta Predictions Mouse
Ranking siRNA ID Sequence Start ? Purification Size ? Price Select
1 SASI_Mm01_00099948 predicted 700
2 SASI_Mm01_00099949 predicted 1370
3 SASI_Mm01_00099950 predicted 1516
4 SASI_Mm01_00099951 predicted 1279
5 SASI_Mm01_00099952 predicted 1092
6 SASI_Mm01_00099954 predicted 865
7 SASI_Mm01_00099955 predicted 923
8 SASI_Mm02_00314956 predicted 1276
9 SASI_Mm01_00099956 predicted 608
10 SASI_Mm01_00099957 predicted 1372
11 SASI_Mm01_00099953 predicted 1450