Human(23683) Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members. [provided by RefSeq, Jul 2008]
Save up to 60% per TRCN when you buy a set of 5 or more with the same options.
MISSION® siRNAs have been designed using a world-class siRNA design algorithm licensed from Rosetta Inpharmatics, a leader in advanced siRNA research. The Rosetta-powered siRNA design algorithm has been optimized with over 3 years of continuous development for enhanced performance in RNAi applications. New and critical siRNA design rules incorporated into the latest algorithm lead to increased target specificity and knockdown for low abundance messages.
Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
Custom Gene Products
Our expertise in DNA & RNA oligo design, chemistry and manufacturing enable Sigma Custom Products to provide a comprehensive product portfolio. Learn more about our "custom capabilities & extensive options today."
siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_005813
Rosetta Predictions
human
pricing
NM_001024263
Rosetta Predictions
rat
pricing
XM_001054495
Rosetta Predictions
rat
pricing
XM_001058887
Rosetta Predictions
rat
pricing
NM_029239
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_029239
PRKD3 MISSION shRNA Bacterial Glycerol Stock protein kinase D3
Mouse
5 Products Total
TRC Number
Price
Set Price (5+)?
Select
We do not support the configuration options you have chosen
