Human(5770) Summary: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Mouse(19246) protein tyrosine phosphatase, non-receptor type 1
Rat(24697) protein tyrosine phosphatase, non-receptor type 1
cow(508658) protein tyrosine phosphatase, non-receptor type 1
sheep(101118209) protein tyrosine phosphatase, non-receptor type 1
dog(477263) protein tyrosine phosphatase, non-receptor type 1
chicken(395688) protein tyrosine phosphatase, non-receptor type 1
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siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_002827
siRNAs that have been validated in the lab
human
pricing
NM_012637
Rosetta Predictions
rat
pricing
NM_011201
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_002827
VALIDATED
PTPN1 MISSION shRNA Bacterial Glycerol Stock protein tyrosine phosphatase, non-receptor type 1
Human
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