Human(6505) Summary: This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]
Mouse(20510) solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Rat(25550) solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Zebrafish(436939) solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chicken(427352) solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
dog(403751) solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
domestic cat(101099844) solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
cow(282353) solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Domestic Rabbit(100009070) solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
naked mole-rat(101713753) solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
domestic guinea pig(100721255) solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
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MISSION® siRNAs have been designed using a world-class siRNA design algorithm licensed from Rosetta Inpharmatics, a leader in advanced siRNA research. The Rosetta-powered siRNA design algorithm has been optimized with over 3 years of continuous development for enhanced performance in RNAi applications. New and critical siRNA design rules incorporated into the latest algorithm lead to increased target specificity and knockdown for low abundance messages.
Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
Custom Gene Products
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siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_004170
Rosetta Predictions
human
pricing
NM_013032
Rosetta Predictions
rat
pricing
NM_009199
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_004170
VALIDATED
SLC1A1 MISSION shRNA Bacterial Glycerol Stock solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Human
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SLC1A1 MISSION shRNA Lentiviral Transduction Particles solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Human
10 Products Total
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SLC1A1 MISSION shRNA Lentiviral Transduction Particles solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Mouse
5 Products Total
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