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SOCS1

suppressor of cytokine signaling 1

102 Gene Product Result for
Synonyms: CIS1 CISH1 JAB SOCS-1 SSI-1 SSI1 TIP3
UniProtKB ID: O15524, O15097, Q9NSA7
Gene ID:
Human(8651) Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]
Mouse(12703) suppressor of cytokine signaling 1
Rat(252971) suppressor of cytokine signaling 1
chicken(416630) suppressor of cytokine signaling 1
dog(490006) suppressor of cytokine signaling 1
cow(518795) suppressor of cytokine signaling 1
sheep(101107324) suppressor of cytokine signaling 1
domestic guinea pig(100728652) suppressor of cytokine signaling 1
naked mole-rat(101729320) suppressor of cytokine signaling 1
Custom Gene Products
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shRNA

Type Description Species Add to Cart
 

esiRNA

Product # Description Species Add to Cart
 
EMU203261 MISSION® esiRNA esiRNA targeting mouse Socs1 mouse pricing

Custom CRISPR Plasmid

Product # Description  
 
CRISPR Custom CRISPR Plasmid for gene knockout

siRNA

siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm.
All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product # siRNA Type Species  
 
NM_003745 Rosetta Predictions human pricing
NM_145879 Rosetta Predictions rat pricing
NM_009896 Rosetta Predictions mouse pricing
siRNA
PRODUCT # siRNA Type ? SPECIES
NM_003745 Rosetta Predictions Human
Ranking siRNA ID Sequence Start ?
1 SASI_Hs01_00093418 predicted 796
2 SASI_Hs02_00336204 predicted 793
3 SASI_Hs01_00093419 predicted 748
4 SASI_Hs02_00336205 predicted 798
5 SASI_Hs01_00093420 predicted 809
6 SASI_Hs01_00093421 predicted 712
7 SASI_Hs01_00093423 predicted 521
8 SASI_Hs02_00336206 predicted 810
9 SASI_Hs01_00093427 predicted 536
10 SASI_Hs02_00336207 predicted 792
11 SASI_Hs01_00093422 predicted 529
12 SASI_Hs01_00093424 predicted 558
13 SASI_Hs01_00093425 predicted 518
14 SASI_Hs01_00093426 predicted 581
siRNA
PRODUCT # siRNA Type ? SPECIES
NM_145879 Rosetta Predictions Rat
Ranking siRNA ID Sequence Start ?
1 SASI_Rn01_00041744 predicted 367
2 SASI_Rn01_00041745 predicted 375
3 SASI_Rn01_00041746 predicted 401
4 SASI_Rn01_00041747 predicted 413
5 SASI_Rn01_00041748 predicted 395
6 SASI_Rn01_00041749 predicted 312
7 SASI_Rn01_00041750 predicted 602
8 SASI_Rn01_00041751 predicted 586
9 SASI_Rn01_00041752 predicted 550
10 SASI_Rn01_00041753 predicted 572
siRNA
PRODUCT # siRNA Type ? SPECIES
NM_009896 Rosetta Predictions Mouse
Ranking siRNA ID Sequence Start ?
1 SASI_Mm01_00047370 predicted 464
2 SASI_Mm01_00047371 predicted 471
3 SASI_Mm01_00047372 predicted 556
4 SASI_Mm01_00047373 predicted 578
5 SASI_Mm01_00047374 predicted 302
6 SASI_Mm01_00047375 predicted 376
7 SASI_Mm01_00047377 predicted 476
8 SASI_Mm01_00047378 predicted 376
9 SASI_Mm02_00317399 predicted 320
10 SASI_Mm01_00047379 predicted 324
11 SASI_Mm01_00047376 predicted 533