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SOST

sclerostin

67 Gene Product Result for
Synonyms: CDD VBCH
UniProtKB ID: Q9BQB4, Q495N9
Gene ID:
Human(50964) Summary: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]
Mouse(74499) sclerostin
Rat(80722) sclerostin
chicken(429784) sclerostin
dog(490948) sclerostin
cow(282880) sclerostin
sheep(101114123) sclerostin
Custom Gene Products
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shRNA

Type Description Species Add to Cart
 

Custom CRISPR Plasmid

Product # Description  
 
CRISPR Custom CRISPR Plasmid for gene knockout

siRNA

siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm.
All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product # siRNA Type Species  
 
NM_025237 Rosetta Predictions human pricing
NM_030584 Rosetta Predictions rat pricing
NM_024449 Rosetta Predictions mouse pricing
siRNA
PRODUCT # siRNA Type ? SPECIES
NM_025237 Rosetta Predictions Human
Ranking siRNA ID Sequence Start ?
1 SASI_Hs01_00038119 predicted 407
2 SASI_Hs01_00038121 predicted 252
3 SASI_Hs01_00038123 predicted 401
4 SASI_Hs01_00038124 predicted 430
5 SASI_Hs02_00358059 predicted 210
6 SASI_Hs02_00358060 predicted 431
7 SASI_Hs02_00358061 predicted 416
8 SASI_Hs02_00358062 predicted 416
9 SASI_Hs01_00038125 predicted 464
10 SASI_Hs01_00038127 predicted 1046
11 SASI_Hs01_00038120 predicted 299
12 SASI_Hs01_00038122 predicted 386
13 SASI_Hs01_00038126 predicted 766
14 SASI_Hs01_00038128 predicted 814
siRNA
PRODUCT # siRNA Type ? SPECIES
NM_030584 Rosetta Predictions Rat
Ranking siRNA ID Sequence Start ?
1 SASI_Rn01_00035441 predicted 318
2 SASI_Rn01_00035442 predicted 304
3 SASI_Rn01_00035443 predicted 242
4 SASI_Rn01_00035444 predicted 259
5 SASI_Rn01_00035445 predicted 406
6 SASI_Rn01_00035446 predicted 426
7 SASI_Rn01_00035447 predicted 377
8 SASI_Rn01_00035448 predicted 446
9 SASI_Rn01_00035449 predicted 318
10 SASI_Rn01_00035450 predicted 243
siRNA
PRODUCT # siRNA Type ? SPECIES
NM_024449 Rosetta Predictions Mouse
Ranking siRNA ID Sequence Start ?
1 SASI_Mm01_00041334 predicted 246
2 SASI_Mm01_00041342 predicted 1175
3 SASI_Mm01_00041335 predicted 1142
4 SASI_Mm01_00041336 predicted 511
5 SASI_Mm01_00041337 predicted 1109
6 SASI_Mm02_00327792 predicted 232
7 SASI_Mm01_00041338 predicted 249
8 SASI_Mm01_00041339 predicted 1134
9 SASI_Mm01_00041341 predicted 1080
10 SASI_Mm01_00041343 predicted 282
11 SASI_Mm01_00041340 predicted 202