Human(10254) Summary: The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]
Mouse(56324) signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Rat(311030) signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Zebrafish(492497) signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
chicken(424317) signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Horse(100057966) signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
cow(538505) signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
sheep(101117649) signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Save up to 60% per TRCN when you buy a set of 5 or more with the same options.
MISSION® siRNAs have been designed using a world-class siRNA design algorithm licensed from Rosetta Inpharmatics, a leader in advanced siRNA research. The Rosetta-powered siRNA design algorithm has been optimized with over 3 years of continuous development for enhanced performance in RNAi applications. New and critical siRNA design rules incorporated into the latest algorithm lead to increased target specificity and knockdown for low abundance messages.
Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
Custom Gene Products
Our expertise in DNA & RNA oligo design, chemistry and manufacturing enable Sigma Custom Products to provide a comprehensive product portfolio. Learn more about our "custom capabilities & extensive options today."
siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_005843
Rosetta Predictions
human
pricing
NM_001012085
Rosetta Predictions
rat
pricing
XM_575133
Rosetta Predictions
rat
pricing
NM_019667
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_005843
VALIDATED
STAM2 MISSION shRNA Bacterial Glycerol Stock signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Human
6 Products Total
TRC Number
Price
Set Price (5+)?
Select
We do not support the configuration options you have chosen