Human(6772) Summary: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Mouse(20846) signal transducer and activator of transcription 1
Rat(25124) signal transducer and activator of transcription 1
chicken(424044) signal transducer and activator of transcription 1, 91kDa
dog(488449) signal transducer and activator of transcription 1, 91kDa
cow(510814) signal transducer and activator of transcription 1, 91kDa
sheep(100307049) signal transducer and activator of transcription 1, 91kDa
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MISSION® siRNAs have been designed using a world-class siRNA design algorithm licensed from Rosetta Inpharmatics, a leader in advanced siRNA research. The Rosetta-powered siRNA design algorithm has been optimized with over 3 years of continuous development for enhanced performance in RNAi applications. New and critical siRNA design rules incorporated into the latest algorithm lead to increased target specificity and knockdown for low abundance messages.
Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
Custom Gene Products
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siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_007315
Rosetta Predictions
human
pricing
NM_139266
Rosetta Predictions
human
pricing
NM_001034164
Rosetta Predictions
rat
pricing
NM_032612
Rosetta Predictions
rat
pricing
NM_009283
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_007315
VALIDATED
STAT1 MISSION shRNA Bacterial Glycerol Stock signal transducer and activator of transcription 1, 91kDa
Human
9 Products Total
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