Human(6774) Summary: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Mouse(20848) signal transducer and activator of transcription 3
Rat(25125) signal transducer and activator of transcription 3 (acute-phase response factor)
cow(508541) signal transducer and activator of transcription 3 (acute-phase response factor)
sheep(100294659) signal transducer and activator of transcription 3 (acute-phase response factor)
naked mole-rat(101721899) signal transducer and activator of transcription 3 (acute-phase response factor)
Domestic Rabbit(100348778) signal transducer and activator of transcription 3 (acute-phase response factor)
Zebrafish(30767) signal transduction and activation of transcription 3
Horse(100052852) signal transducer and activator of transcription 3 (acute-phase response factor)
domestic cat(101095698) signal transducer and activator of transcription 3 (acute-phase response factor)
dog(490967) signal transducer and activator of transcription 3 (acute-phase response factor)
chicken(420027) signal transducer and activator of transcription 3 (acute-phase response factor)
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MISSION® siRNAs have been designed using a world-class siRNA design algorithm licensed from Rosetta Inpharmatics, a leader in advanced siRNA research. The Rosetta-powered siRNA design algorithm has been optimized with over 3 years of continuous development for enhanced performance in RNAi applications. New and critical siRNA design rules incorporated into the latest algorithm lead to increased target specificity and knockdown for low abundance messages.
Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
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siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_003150
siRNAs that have been validated in the lab
human
pricing
NM_139276
siRNAs that have been validated in the lab
human
pricing
NM_213662
siRNAs that have been validated in the lab
human
pricing
NM_012747
Rosetta Predictions
rat
pricing
NM_011486
Rosetta Predictions
mouse
pricing
NM_213659
Rosetta Predictions
mouse
pricing
NM_213660
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_003150
VALIDATED
STAT3 MISSION shRNA Bacterial Glycerol Stock signal transducer and activator of transcription 3 (acute-phase response factor)
Human
9 Products Total
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