Human(6775) Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
Mouse(20849) signal transducer and activator of transcription 4
Rat(367264) signal transducer and activator of transcription 4
Zebrafish(368519) signal transducer and activator of transcription 4
chicken(768406) signal transducer and activator of transcription 4
dog(478845) signal transducer and activator of transcription 4
cow(515988) signal transducer and activator of transcription 4
sheep(101117562) signal transducer and activator of transcription 4
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MISSION® siRNAs have been designed using a world-class siRNA design algorithm licensed from Rosetta Inpharmatics, a leader in advanced siRNA research. The Rosetta-powered siRNA design algorithm has been optimized with over 3 years of continuous development for enhanced performance in RNAi applications. New and critical siRNA design rules incorporated into the latest algorithm lead to increased target specificity and knockdown for low abundance messages.
Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
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siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_003151
Rosetta Predictions
human
pricing
NM_001012226
Rosetta Predictions
rat
pricing
XM_576563
Rosetta Predictions
rat
pricing
NM_011487
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_011487
STAT4 MISSION shRNA Bacterial Glycerol Stock signal transducer and activator of transcription 4
Mouse
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