Human(6778) Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Mouse(20852) signal transducer and activator of transcription 6
Rat(362896) signal transducer and activator of transcription 6, interleukin-4 induced
Zebrafish(337413) signal transducer and activator of transcription 6, interleukin-4 induced
Horse(100050053) signal transducer and activator of transcription 6, interleukin-4 induced
domestic cat(101089873) signal transducer and activator of transcription 6, interleukin-4 induced
dog(100142679) signal transducer and activator of transcription 6, interleukin-4 induced
chicken(100859196) signal transducer and activator of transcription 6, interleukin-4 induced
cow(353105) signal transducer and activator of transcription 6, interleukin-4 induced
sheep(101102134) signal transducer and activator of transcription 6, interleukin-4 induced
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Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
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Product #
siRNA Type
Species
NM_003153
Rosetta Predictions
human
pricing
NM_001044250
Rosetta Predictions
rat
pricing
NM_009284
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_003153
VALIDATED
STAT6 MISSION shRNA Bacterial Glycerol Stock signal transducer and activator of transcription 6, interleukin-4 induced
Human
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