Human(7341) Summary: This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
Mouse(22218) SMT3 suppressor of mif two 3 homolog 1 (yeast)
cow(614967) SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
Goat(100861153) SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
sheep(101110738) SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
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MISSION® siRNAs have been designed using a world-class siRNA design algorithm licensed from Rosetta Inpharmatics, a leader in advanced siRNA research. The Rosetta-powered siRNA design algorithm has been optimized with over 3 years of continuous development for enhanced performance in RNAi applications. New and critical siRNA design rules incorporated into the latest algorithm lead to increased target specificity and knockdown for low abundance messages.
Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
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siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_001005781
Rosetta Predictions
human
pricing
NM_001005782
Rosetta Predictions
human
pricing
NM_003352
Rosetta Predictions
human
pricing
NM_001009672
Rosetta Predictions
rat
pricing
NM_009460
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_009460
VALIDATED
SUMO1 MISSION shRNA Bacterial Glycerol Stock small ubiquitin-like modifier 1
Mouse
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